2. Gene
  3. CHTOP - chromatin target of PRMT1 Gene

CHTOP - chromatin target of PRMT1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FOP; SRAG; SRAG-3; SRAG-5; pp7704; C1orf77; FL-SRAG; C10orf77

Gene ID: 26097 | Gene type: protein coding

About CHTOP

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,634,066-153,646,306 (from NCBI)

This gene has 7 transcripts (splice variants), 261 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 21.4), spleen (RPKM 20.4) and 25 other tissues.

Summary

This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]

CHTOP Products(4)

mRNA Protein Name
NM_001206612.2 NP_001193541.1 chromatin target of PRMT1 protein isoform 2
NM_001244664.2 NP_001231593.1 chromatin target of PRMT1 protein isoform 3
NM_001317077.2 NP_001304006.1 chromatin target of PRMT1 protein isoform 4
NM_015607.4 NP_056422.2 chromatin target of PRMT1 protein isoform 1

CHTOP Protein Structure

FoP_duplication

FoP_duplication: C-terminal duplication domain of Friend of PRMT1 (178 - 244)

  • 0
  • 100
  • 200
  • 248 a.a.
Protein Preferred Names Protein Names

chromatin target of PRMT1 protein

friend of PRMT1 protein

Related Diseases

Diseases Alias
Autosomal Dominant Beta Thalassemia

Inclusion Body Beta-Thalassemia
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Farmer'S Lung

Farmer Lung

Farmers Lung

Farmer'S Lung Disease

Farmers' Lung

Farmers' Lung Disease

Mouldy Hay Disease

Moldy Hay Disorder

Fibrosis Of Lung With Farmers' Lung

Harvesters' Hypersensitivity Pneumonitis

Moldy Hay Pneumoconiosis

Haymakers' Hypersensitivity Pneumonitis

Threshers' Lung

Harvester Lung

Haymaker Lung
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02697 CHTOP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHTOP VGNC VGNC:53336
Bos taurus CHTOP VGNC VGNC:27353
Macaca mulatta CHTOP VGNC VGNC:71090
Mus musculus CHTOP MGD MGI:1913761
Rattus norvegicus CHTOP RGD RGD:1359407
Felis catus CHTOP VGNC VGNC:107858