FBXO4 - F-box protein 4 Gene

Homo sapiens

Also known as FBX4

Gene ID: 26272 | Gene type: protein coding

About FBXO4

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:41,925,281-42,040,404 (from NCBI)

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in thyroid (RPKM 3.2), lymph node (RPKM 2.5) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

FBXO4 Products(3)

mRNA	Protein	Name
NM_001297437.2	NP_001284366.1	F-box only protein 4 isoform 3
NM_012176.3	NP_036308.1	F-box only protein 4 isoform 1
NM_033484.3	NP_277019.1	F-box only protein 4 isoform 2

FBXO4 Protein Structure

F-box

0
100
200
300
387 a.a.

Protein Preferred Names

Protein Names

F-box only protein 4

F-box protein Fbx4

Related Diseases

Diseases

Alias

Dyskeratosis Congenita, Autosomal Dominant 3

DKCA3	Autosomal Dominant Dyskeratosis Congenita 3
Dyskeratosis Congenita, Autosomal Dominant, 3	Dyskeratosis Congenita, Autosomal Dominant, Type 3

Dyskeratosis Congenita, Autosomal Recessive 6

DKCB6	Autosomal Recessive Dyskeratosis Congenita 6
Dyskeratosis Congenita, Autosomal Recessive, 6	Dyskeratosis Congenita, Autosomal Recessive, Type 6

Dyskeratosis Congenita, Autosomal Recessive 1

DKCB1	Autosomal Recessive Dyskeratosis Congenita 1
Dyskeratosis Congenita, Autosomal Recessive, 1	Dyskeratosis Congenita, Autosomal Recessive, Type 1

Dyskeratosis Congenita, Autosomal Recessive 3

DKCB3	Autosomal Recessive Dyskeratosis Congenita 3
Dyskeratosis Congenita, Autosomal Recessive, 3	Dyskeratosis Congenita, Autosomal Recessive, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04806	FBXO4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FBXO4	MGD	MGI:2146220
Felis catus	FBXO4	VGNC	VGNC:62191
Canis familiaris	FBXO4	VGNC	VGNC:40779
Bos taurus	FBXO4	VGNC	VGNC:28910
Rattus norvegicus	FBXO4	RGD	RGD:1307580
Macaca mulatta	FBXO4	VGNC	VGNC:72488
Others	FBXO4	NCBI

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