2. Gene
  3. Esrrb - estrogen related receptor, beta Gene

Esrrb - estrogen related receptor, beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Err2; Errb; Nr3b2; Estrrb

Gene ID: 26380 | Gene type: protein coding

About Esrrb

Chromosome 12: 86,407,891-86,568,402 forward strand.GRCm39:CM001005.3

This gene has 6 transcripts (splice variants), 264 orthologues, 8 paralogues and is associated with 15 phenotypes. Biased expression in kidney adult (RPKM 6.2), heart adult (RPKM 4.9) and 12 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II complex binding activity. Involved in several processes, including photoreceptor cell maintenance; positive regulation of stem cell population maintenance; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within in utero embryonic development and positive regulation of transcription by RNA polymerase II. Located in condensed chromosome; cytoplasm; and nucleus. Part of integrator complex. Is expressed in several structures, including central nervous system; early conceptus; endocrine gland; gonad; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Esrrb Products(2)

mRNA Protein Name
NM_001159500.1 NP_001152972.1 steroid hormone receptor ERR2 isoform 2
NM_011934.4 NP_036064.3 steroid hormone receptor ERR2 isoform 1

Esrrb Protein Structure

NR_DBD_ERR

NR_DBD_ERR: cd07170 (118 - 213)

NR_LBD_ERR

NR_LBD_ERR: cd06946 (232 - 451)

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  • 454 a.a.
Protein Preferred Names Protein Names

steroid hormone receptor ERR2

ERR-beta

estrogen receptor related 2

estrogen receptor-like 2

nuclear receptor subfamily 3 group B member 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04540 ESRRB Human Pre-designed siRNA Set A / Unkown
HY-RS04541 Esrrb Mouse Pre-designed siRNA Set A / Unkown
HY-RS04542 ESRRB Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esrrb NCBI NCBI:2103