Map3k8 - mitogen-activated protein kinase kinase kinase 8 Gene

Mus musculus

Also known as Cot; Est; Estf; Tpl2; Tpl-2; c-COT; Cot/Tpl2

Gene ID: 26410 | Gene type: protein coding

About Map3k8

Chromosome 18: 4,331,327-4,353,015 reverse strand.GRCm39:CM001011.3

This gene has 5 transcripts (splice variants), 199 orthologues, 35 paralogues and is associated with 34 phenotypes. Ubiquitous expression in spleen adult (RPKM 3.1), lung adult (RPKM 2.9) and 27 other tissues.

Summary

Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in protein phosphorylation and signal transduction. Predicted to act upstream of or within immune system process and phosphorylation. Predicted to be located in cytosol. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; hemolymphoid system gland; and reproductive system. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Map3k8 Products(1)

mRNA	Protein	Name
NM_007746.2	NP_031772.1	mitogen-activated protein kinase kinase kinase 8

Map3k8 Protein Structure

STKc_MAP3K8

0
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300
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467 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 8

COT proto-oncogene serine/threonine-protein kinase	cancer Osaka thyroid oncogene
proto-oncogene c-Cot	serine/threonine-protein kinase cot
tumor progression locus 2

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12358	Tpl2 Kinase Inhibitor 1	Inhibitor	99.22%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k8	NCBI	NCBI:1326