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  3. FOXP1 - forkhead box P1 Gene

FOXP1 - forkhead box P1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MFH; QRF1; 12CC4; hFKH1B; HSPC215

Gene ID: 27086 | Gene type: protein coding

About FOXP1

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:70,954,708-71,583,978 (from NCBI)

This gene has 71 transcripts (splice variants), 131 orthologues, 42 paralogues and is associated with 104 phenotypes. Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues.

Summary

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

FOXP1 Products(17)

mRNA Protein Name
NM_001012505.2 NP_001012523.1 forkhead box protein P1 isoform b
NM_001244808.3 NP_001231737.1 forkhead box protein P1 isoform c
NM_001244810.2 NP_001231739.1 forkhead box protein P1 isoform d
NM_001244812.3 NP_001231741.1 forkhead box protein P1 isoform e
NM_001244813.3 NP_001231742.1 forkhead box protein P1 isoform f
NM_001244814.3 NP_001231743.1 forkhead box protein P1 isoform a
NM_001244815.2 NP_001231744.2 forkhead box protein P1 isoform f
NM_001244816.2 NP_001231745.1 forkhead box protein P1 isoform a
NM_001349337.2 NP_001336266.2 forkhead box protein P1 isoform i
NM_001349338.3 NP_001336267.1 forkhead box protein P1 isoform a
NM_001349340.3 NP_001336269.1 forkhead box protein P1 isoform a
NM_001349341.3 NP_001336270.1 forkhead box protein P1 isoform j
NM_001349342.3 NP_001336271.1 forkhead box protein P1 isoform f
NM_001349343.3 NP_001336272.1 forkhead box protein P1 isoform i
NM_001349344.3 NP_001336273.1 forkhead box protein P1 isoform i
NM_001370548.1 NP_001357477.1 forkhead box protein P1 isoform k
NM_032682.6 NP_116071.2 forkhead box protein P1 isoform a

FOXP1 Protein Structure

Forkhead

Forkhead: Forkhead domain (465 - 545)

  • 0
  • 200
  • 400
  • 600
  • 677 a.a.
Protein Preferred Names Protein Names

forkhead box protein P1

fork head-related protein like B

Related Diseases

Diseases Alias
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome

Mental Retardation With Language Impairment And With Or Without Autistic Features

Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects

Intellectual Disability With Language Impairment And With Or Without Autistic Features
Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features

Mental Retardation With Language Impairment And With Or Without Autistic Features

Intellectual Developmental Disorder With Language Impairment With Or Without Autistic Features

MRLIAF
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Atrial Septal Defect 1

ASD1

Atrial Heart Septal Defect 1

Asd
Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Earlobe Crease
Rare Genetic Intellectual Disability
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
Speech Disorder

Speech Disorders
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos
B-Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like

B Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like

B-All Bcr-Abl1-Like
Blepharophimosis
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia

HH4

Kallmann Syndrome 4

Kal4

Hypogonadotropic Hypogonadism, Type 4 With/Without Anosmia
Megalencephaly

Macroencephaly

Macrencephaly
Alpha Chain Disease

Seligmann'S Disease

Immunoproliferative Small Intestinal Disease
Orbit Lymphoma

Orbital Lymphoma

Lymphoma Of The Orbit
Speech And Communication Disorders

Language Disorder

Communication Disorder

Language Disorders

Communication Disorders

Speech Language Disorder

Speech-Language Disorder

Communication Impairment

Speech And Language Disorder
Congenital Disorder Of Glycosylation, Type Ig

CDG1G

Alg12-Congenital Disorder Of Glycosylation

Cdg Ig

Congenital Disorder Of Glycosylation Type 1g

Congenital Disorder Of Glycosylation Type Ig

Cdgig

Congenital Disorder Of Glycosylation Ig

Congenital Disorder Of Glycosylation 1g

Cdg-Ig

Alg12-Cdg

Cdg Syndrome Type Ig

Carbohydrate Deficient Glycoprotein Syndrome Type Ig

Mannosyltransferase 8 Deficiency

Glycosylation, Congenital Disorder Of, Type Ig
Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma

Mzl

Mucosa-Associated Lymphoid Tissue Lymphoma
Specific Language Impairment

Language Impairment, Specific
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05073 FOXP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FOXP1 VGNC VGNC:29101
Felis catus FOXP1 VGNC VGNC:62345
Mus musculus FOXP1 MGD MGI:1914004
Rattus norvegicus FOXP1 RGD RGD:1308669
Canis familiaris FOXP1 VGNC VGNC:40965
Macaca mulatta FOXP1 VGNC VGNC:84173