KCNMB3 - potassium calcium-activated channel subfamily M regulatory beta subunit 3 Gene

Homo sapiens

Also known as HBETA3; KCNMB2; KCNMBL; BKBETA3; SLOBETA3; SLO-BETA-3; K(VCA)BETA-3

Gene ID: 27094 | Gene type: protein coding

About KCNMB3

Cytogenetic location: 3q26.32 Genomic coordinates (GRCh38): 3:179,239,703-179,267,050 (from NCBI)

This gene has 7 transcripts (splice variants), 162 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 6.7), gall bladder (RPKM 6.6) and 25 other tissues.

Summary

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]

KCNMB3 Products(5)

mRNA	Protein	Name
NM_001163677.2	NP_001157149.1	calcium-activated potassium channel subunit beta-3 isoform e
NM_014407.3	NP_055222.3	calcium-activated potassium channel subunit beta-3 isoform d
NM_171828.3	NP_741979.1	calcium-activated potassium channel subunit beta-3 isoform a
NM_171829.3	NP_741980.1	calcium-activated potassium channel subunit beta-3 isoform b
NM_171830.2	NP_741981.1	calcium-activated potassium channel subunit beta-3 isoform c

KCNMB3 Protein Structure

CaKB

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

calcium-activated potassium channel subunit beta-3

BK channel beta subunit 3

Related Diseases

Diseases

Alias

Epilepsy, Familial Adult Myoclonic, 5

FAME5	Fcmte5
Cortical Myoclonic Tremor With Epilepsy, Familial, 5	Familial Adult Myoclonic Epilepsy 5
Epilepsy, Myoclonic, Familial Adult, 5	Familial Cortical Myoclonic Tremor And Epilepsy 5
Familial Cortical Myoclonic Tremor With Epilepsy 5	Epilepsy, Myoclonic, Familial Adult, Type 5

Familial Febrile Seizures

Familial Febrile Convulsions	Feb
Febrile Seizures, Familial

Severe Congenital Neutropenia 3

Kostmann Syndrome	Infantile Agranulocytosis
Kostmann Disease	Scn3
Severe Congenital Neutropenia Type 3

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy	Generalised Epilepsy
Epilepsy, Generalized	EIG
Ige	Epilepsy, Idiopathic Generalized, Susceptibility To, 1
Epilepsy, Idiopathic Generalized 1	Epilepsy, Idiopathic Generalized, Susceptibility To
Epilepsy, Idiopathic, Generalized	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Adnfle	Autosomal Dominant Sleep-Related Hypermotor Epilepsy
Enfl	Benign Familial Infantile Seizures 6
Benign Familial Infantile Seizures, 6	Nocturnal Frontal Lobe Epilepsy-4
Enfl1	Epilepsy, Nocturnal Frontal Lobe, 1
Epilepsy, Nocturnal Frontal Lobe, Type 1

Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy	Janz Syndrome
Jme	Myoclonic Epilepsy, Juvenile, Susceptibility To, 1
EJM	Myoclonic Epilepsy, Juvenile
Petit Mal, Impulsive	Myoclonic Epilepsy, Juvenile 1
Myoclonic Epilepsy, Juvenile, 1	Adolescent Myoclonic Epilepsy
Juvenile Myoclonus Epilepsy	Juvenile Myoclonic Epilepsy 1
EJM1	Petit Mal Impulsive
Susceptibility To Juvenile Myoclonic Epilepsy 1	Myoclonic Epilepsy Juvenile
Epilepsy, Myoclonic, Juvenile	Myoclonic Epilepsy Of Janz
Jme - [Juvenile Myoclonic Epilepsy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07167	KCNMB3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCNMB3	MGD	MGI:3612244
Felis catus	KCNMB3	VGNC	VGNC:102764
Macaca mulatta	KCNMB3	VGNC	VGNC:74000
Canis familiaris	KCNMB3	VGNC	VGNC:42283
Rattus norvegicus	KCNMB3	RGD	RGD:1311852
Bos taurus	KCNMB3	VGNC	VGNC:30481

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