POLM - DNA polymerase mu Gene

Homo sapiens

Also known as Tdt-N; Pol Mu

Gene ID: 27434 | Gene type: protein coding

About POLM

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,072,062-44,082,530 (from NCBI)

This gene has 18 transcripts (splice variants), 185 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 6.9), lymph node (RPKM 5.6) and 25 other tissues.

Summary

Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within B cell differentiation and somatic hypermutation of immunoglobulin genes. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

POLM Products(4)

mRNA	Protein	Name
NM_001284330.2	NP_001271259.1	DNA-directed DNA/RNA polymerase mu isoform 2
NM_001284331.2	NP_001271260.1	DNA-directed DNA/RNA polymerase mu isoform 3
NM_001362683.2	NP_001349612.1	DNA-directed DNA/RNA polymerase mu isoform 4
NM_013284.4	NP_037416.1	DNA-directed DNA/RNA polymerase mu isoform 1

POLM Protein Structure

HHH_8

DNA_pol_lambd_f

DNA_pol_B_palm

DNA_pol_B_thumb

0
100
200
300
400
494 a.a.

Protein Preferred Names

Protein Names

DNA-directed DNA/RNA polymerase mu

Pol iota

Related Diseases

Diseases

Alias

Nemaline Myopathy 3

Nemaline Myopathy 3, Autosomal Dominant Or Recessive	Congenital Myopathy With Excess Of Thin Filaments
NEM3	Myopathy, Actin, Congenital, With Cores
Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments	Actin-Accumulation Myopathy
Actin Myopathy	Actin Accumulation Myopathy
Actin Filament Aggregate Myopathy	Nemaline Myopathy, Type 3
MPCETM	Acta1-Related Nemaline Myopathy
Actin Myopathy Congenital With Cores	Nemaline Myopathy 3 With Intranuclear Rods
Myopathy, Nemaline, Type 3

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Lig4 Syndrome

Dna Ligase Iv Deficiency	Ligase 4 Syndrome
LIG4S

Lung Adenoma

Adenoma Of Lung

Pulmonary Adenoma

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10834	POLM Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POLM	VGNC	VGNC:33128
Mus musculus	POLM	MGD	MGI:1860191
Rattus norvegicus	POLM	RGD	RGD:1308247
Macaca mulatta	POLM	VGNC	VGNC:81742
Felis catus	POLM	VGNC	VGNC:68945
Canis familiaris	POLM	VGNC	VGNC:103698