GNAI1 - G protein subunit alpha i1 Gene

Homo sapiens

Also known as Gi; HG1B; NEDHISB

Gene ID: 2770 | Gene type: protein coding

About GNAI1

Cytogenetic location: 7q21.11 Genomic coordinates (GRCh38): 7:80,134,831-80,226,181 (from NCBI)

This gene has 32 transcripts (splice variants), 224 orthologues, 15 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 39.3), brain (RPKM 28.1) and 22 other tissues.

Summary

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting Adenylate Cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GNAI1 Products(2)

mRNA	Protein	Name
NM_001256414.2	NP_001243343.1	guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 2
NM_002069.6	NP_002060.4	guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1

GNAI1 Protein Structure

G-alpha

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(i) subunit alpha-1

Gi1 protein alpha subunit

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Hypotonia, Impaired Speech, And Behavioral Abnormalities

NEDHISB

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Pertussis

Whooping Cough	Bordetella Infections
Bordetella Infection	Bordetella Pertussis Infection
Wc - Whooping Cough	Whooping Cough Due To Unspecified Organism
Bordetellosis	Tussis Convulsiva
Whooping Cough, Unspecified Organism	Wc - [Whooping Cough]
Whooping Cough Due To B. Parapertussis	Infection Due To Bordetella Parapertussis

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Night Blindness

Nyctalopia

Pilomyxoid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05534	GNAI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GNAI1	MGD	MGI:95771
Canis familiaris	GNAI1	VGNC	VGNC:41301
Bos taurus	GNAI1	VGNC	VGNC:29449
Felis catus	GNAI1	VGNC	VGNC:62616
Rattus norvegicus	GNAI1	RGD	RGD:2713
Macaca mulatta	GNAI1	VGNC	VGNC:73089

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