GNAL - G protein subunit alpha L Gene

Homo sapiens

Also known as HG1O; DYT25

Gene ID: 2774 | Gene type: protein coding

About GNAL

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:11,689,264-11,885,685 (from NCBI)

This gene has 10 transcripts (splice variants), 233 orthologues, 15 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 7.2), prostate (RPKM 5.5) and 24 other tissues.

Summary

This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GNAL Products(5)

mRNA	Protein	Name
NM_001142339.3	NP_001135811.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 2
NM_001261443.2	NP_001248372.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 2
NM_001261444.2	NP_001248373.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 3
NM_001369387.1	NP_001356316.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 2
NM_182978.4	NP_892023.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 1

GNAL Protein Structure

G-alpha

0
100
200
300
381 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(olf) subunit alpha

adenylate cyclase-stimulating G alpha protein, olfactory type

Related Diseases

Diseases

Alias

Dystonia 25

DYT25	Dystonia-25
Dystonia, Type 25

Dyt-Gnal

Dyt25	Autosomal Dominant Focal Dystonia, Dyt25 Type
Gnal-Related Dystonia	Adult Onset Cranial-Cervical Dystonia
Dystonia-25	Dystonia 25

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Pseudohypoparathyroidism

Familial Pseudohypoparathyroidism	Parathyroid Hormone Resistant Hypoparathyroidism
Php - [Pseudohypoparathyroidism]	Constitutional Chronic Hypocalcaemia

Focal Dystonia

Dystonia, Focal, Task-Specific

Spasmodic Dystonia

Laryngeal Dystonia

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Segmental Dystonia

Dystonia 24

DYT24	Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement
Dystonia-24	Dystonia, Type 24

Dystonia 12

DYT12	Rdp
Generalized Dystonia	Dystonia-12
Rapid-Onset Dystonia-Parkinsonism	Familial Dystonia
Dystonia Musculorum Deformans	Dystonic Disorders
Idiopathic Familial Dystonia	Dystonia-Parkinsonism, Rapid-Onset
Fragments Of Torsion Dystonia	Dyt-Atp1a3
Rapid-Onset Dystonia Parkinsonism	Rodp
Dystonia, Type 12	Dystonia 3, Torsion, X-Linked
Idiopathic Non-Familial Dystonia	Symptomatic Torsion Dystonia
Dystonia Disorders

Focal Hand Dystonia

Organic Writer'S Cramp

Dystonia, Focal, Task-Specific

Torsion Dystonia 2

Dystonia 2, Torsion, Autosomal Recessive

Cervical Dystonia

Spasmodic Torticollis

Torsion Dystonia 4

Multifocal Dystonia

Dystonia 1, Torsion, Autosomal Dominant

Dystonia Musculorum Deformans 1	Dystonia Musculorum Deformans
DYT1	Early-Onset Torsion Dystonia
Eotd	Dystonia-1, Torsion
Torsion Dystonia 1	Autosomal Dominant Torsion Dystonia 1
Dystonia-1	Oppenheim'S Dystonia
Oppenheim-Ziehen Disease	Early Onset Torsion Dystonia
Dystonia 3, Torsion, X-Linked

Hereditary Lymphedema Ii

Meige Syndrome	Meige Disease
Meige Lymphedema	Hereditary Lymphedema Type Ii
Lymphedema Hereditary Type 2	Lymphedema Praecox
Lymphedema, Hereditary, Ii	Blepharospasm-Oromandibular Dystonia Syndrome
Meige Dystonia	Meige'S Syndrome
Late-Onset Lymphedema	Lmph2
Lymphedema Preacox	Lymphedema, Late-Onset
Blepharospasm - Oromandibular Dystonia	Blepharospasm-Oromandibular Dystonia
Brueghel Syndrome	Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome
Oral Facial Dystonia	Segmental Cranial Dystonia
Meigs Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Blepharospasm

Oromandibular Dystonia

Lymphatic Malformation 5

Meige Syndrome	Meige Disease
Meige Lymphedema	Lymphedema Praecox
Lymphedema, Late-Onset	Late-Onset Lymphedema
LMPH2	Meigs Syndrome
LMPHM5	Lymphedema, Hereditary, Ii, Formerly
Lmph2, Formerly	Hereditary Lymphedema Ii
Demons-Meigs Syndrome	Hereditary Lymphedema Type Ii
Lymphedema, Hereditary, 2	Lymphedema, Hereditary, Ii
Meige'S Disease

Dystonia 27

DYT27	Primary Dystonia, Dyt27 Type
Dystonia, Type 27

Hemidystonia

Developmental And Epileptic Encephalopathy 17

DEE17	Epileptic Encephalopathy, Early Infantile, 17
Eiee17	Developmental And Epileptic Encephalopathy, 17
Early Infantile Epileptic Encephalopathy 17	Developmental And Epileptic Encephalopathy, Type 17

Leukodystrophy, Hypomyelinating, 6

Habc	Hypomyelinating Leukodystrophy 6
HLD6	H-Abc
Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum	Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum
Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum	HLD
Leukodystrophy, Hypomyelinating, Type 6

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Dystonia 11, Myoclonic

Myoclonic Dystonia	Myoclonus-Dystonia Syndrome
DYT11	Myoclonic Dystonia 11
Alcohol-Responsive Dystonia	Myoclonus, Hereditary Essential
Dystonia-11, Myoclonic	Myoclonus-Dystonia
Dystonia 11	Hereditary Essential Myoclonus
Dystonia, Alcohol-Responsive	Dyt-Sgce
Dystonia, Alcohol Responsive	Dystonia-11
Dystonia, Myoclonic	Dystonia, Myoclonic, Type 11

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Movement Disease

Movement Disorders

Movement Disorder

Alternating Hemiplegia Of Childhood

Alternating Hemiplegia	Ahc
Alternating Hemiplegia Syndrome	Hemiplegia, Alternating, Of Childhood
Hemiplegia, Crossed

Choreatic Disease

Chorea

Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05537	GNAL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GNAL	VGNC	VGNC:29452
Felis catus	GNAL	VGNC	VGNC:62618
Macaca mulatta	GNAL	VGNC	VGNC:104224
Mus musculus	GNAL	MGD	MGI:95774
Canis familiaris	GNAL	VGNC	VGNC:41304
Rattus norvegicus	GNAL	RGD	RGD:2715
Macaca fascicularis	GNAL	NCBI
Others	GNAL	NCBI