GNG5 - G protein subunit gamma 5 Gene

Homo sapiens

Gene ID: 2787 | Gene type: protein coding

About GNG5

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,498,325-84,506,581 (from NCBI)

This gene has 5 transcripts (splice variants), 176 orthologues and 11 paralogues. Ubiquitous expression in colon (RPKM 64.2), bone marrow (RPKM 52.7) and 25 other tissues.

Summary

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

GNG5 Products(1)

mRNA	Protein	Name
NM_005274.3	NP_005265.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

GNG5 Protein Structure

G-gamma

0
68 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

guanine nucleotide binding protein (G protein), gamma 5

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05559	GNG5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GNG5	RGD	RGD:620807
Macaca mulatta	GNG5	VGNC	VGNC:106373
Mus musculus	GNG5	MGD	MGI:109164
Canis familiaris	GNG5	VGNC	VGNC:41321