GDPD1 - glycerophosphodiester phosphodiesterase domain containing 1 Gene

Homo sapiens

Also known as GDE4

Gene ID: 284161 | Gene type: protein coding

About GDPD1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:59,220,511-59,275,970 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues and 5 paralogues. Broad expression in brain (RPKM 4.9), testis (RPKM 3.0) and 22 other tissues.

Summary

This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GDPD1 Products(3)

mRNA	Protein	Name
NM_001165993.2	NP_001159465.1	lysophospholipase D GDPD1 isoform 3
NM_001165994.2	NP_001159466.1	lysophospholipase D GDPD1 isoform 2
NM_182569.4	NP_872375.2	lysophospholipase D GDPD1 isoform 1

GDPD1 Protein Structure

GDPD

0
100
200
314 a.a.

Protein Preferred Names

Protein Names

lysophospholipase D GDPD1

glycerophosphodiester phosphodiesterase 4

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 17

RP17	Retinitis Pigmentosa-17
Retinitis Pigmentosa, Type 17

Branchiooculofacial Syndrome

Branchio-Oculo-Facial Syndrome	BOFS
Bof Syndrome	Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome
Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome	Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging
Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging	Bofs Syndrome
Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05362	GDPD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GDPD1	VGNC	VGNC:49766
Felis catus	GDPD1	VGNC	VGNC:99062
Bos taurus	GDPD1	VGNC	VGNC:29310
Macaca mulatta	GDPD1	VGNC	VGNC:99154
Mus musculus	GDPD1	MGD	MGI:1913819
Rattus norvegicus	GDPD1	RGD	RGD:1311813

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