KRT6C - keratin 6C Gene

Homo sapiens

Also known as K6E; KRT6E; PPKNEFD

Gene ID: 286887 | Gene type: protein coding

About KRT6C

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,468,516-52,473,805 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues, 68 paralogues and is associated with 2 phenotypes. Restricted expression toward esophagus (RPKM 948.5).

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]

KRT6C Products(1)

mRNA	Protein	Name
NM_173086.5	NP_775109.2	keratin, type II cytoskeletal 6C

KRT6C Protein Structure

Filament

0
100
200
300
400
500
564 a.a.

Protein Preferred Names

Protein Names

keratin, type II cytoskeletal 6C

CK-6C

Related Diseases

Diseases

Alias

Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

PPKNEFD	Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma
Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering	Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse
Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse

Focal Palmoplantar Keratoderma

Focal Ppk	Focal Keratosis Palmoplantaris
Focal Palmoplantar Hyperkeratosis

Diffuse Palmoplantar Keratoderma

Diffuse Palmoplantar Hyperkeratosis	Diffuse Ppk
Diffuse Keratosis Palmoplantaris

Norwegian Scabies

Crusted Scabies

Seven Year Itch

Pachyonychia Congenita 1

Pachyonychia Congenita	Jadassohn-Lewandowsky Syndrome
Pachyonychia Congenita Syndrome	PC1
Pachyonychia Congenita, Jadassohn-Lewandowsky Type	Congenital Pachyonychia
Pachyonychia Congenita, Type 1	Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly
Jadassohn-Lewandowsky Syndrome, Formerly	Jackson-Lawler Type Pachyonychia Congenita
Pachyonychia Congenita Type 1	Jackson-Lawler Syndrome
Jadassohn-Lewandowski Syndrome	Pc
Pachyonychia Congenita Jackson-Lawler Type	Pachyonychia Congenita Jadassohn-Lewandowsky Type
Pachyonychia Congenita Jackson Lawler Type	Pc-1
Pachyonychia Congenita, Jadassohn Lewandowsky Type	Pachyonychia Congenita, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07460	KRT6C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KRT6C	RGD	RGD:1588056

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