ATAD2 - ATPase family AAA domain containing 2 Gene

Homo sapiens

Also known as ANCCA; CT137; PRO2000

Gene ID: 29028 | Gene type: protein coding

About ATAD2

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:123,319,850-123,416,350 (from NCBI)

This gene has 8 transcripts (splice variants), 232 orthologues and 1 paralogue. Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues.

Summary

A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 Amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

ATAD2 Products(1)

mRNA	Protein	Name
NM_014109.4	NP_054828.2	ATPase family AAA domain-containing protein 2

ATAD2 Protein Structure

AAA

Bromodomain

0
300
600
900
1200
1390 a.a.

Protein Preferred Names

Protein Names

ATPase family AAA domain-containing protein 2

AAA nuclear coregulator cancer-associated protein

Related Diseases

Diseases

Alias

Uterine Corpus Endometrial Carcinoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119254	BAY-850	Inhibitor	99.83%	Unkown
HY-136521	AZ13824374	Inhibitor	98.86%	Unkown
HY-114204	GSK8814	Inhibitor	99.60%	Unkown
HY-163108	ATAD2-IN-1		/	Unkown
HY-P10326	Z-ATAD-FMK	Inhibitor	/	Unkown
HY-RS01119	ATAD2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01120	ATAD2B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATAD2	VGNC	VGNC:59989
Mus musculus	ATAD2	MGD	MGI:1917722
Canis familiaris	ATAD2	VGNC	VGNC:38201
Rattus norvegicus	ATAD2	RGD	RGD:1304849
Bos taurus	ATAD2	VGNC	VGNC:26233
Macaca mulatta	ATAD2	VGNC	VGNC:70154

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