2. Gene
  3. H1-2 - H1.2 linker histone, cluster member Gene

H1-2 - H1.2 linker histone, cluster member Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as H1C; H1.2; H1F2; H1s-1; HIST1H1C

Gene ID: 3006 | Gene type: protein coding

About H1-2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,055,740-26,056,470 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-2 Products(1)

mRNA Protein Name
NM_005319.4 NP_005310.1 histone H1.2

H1-2 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (38 - 109)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

histone H1.2

H1 histone family, member 2

Related Diseases

Diseases Alias
Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy

Steele-Richardson-Olszewski Syndrome

Supranuclear Palsy, Progressive

Progressive Supranuclear Ophthalmoplegia

Psp

PSNP1

Familial Progressive Supranuclear Palsy

Richardson'S Syndrome

Psp Syndrome

Progressive Supranuclear Palsy 1

Supranuclear Palsy Progressive

Ophthalmoplegia, Supranuclear, Progressive

Steele-Richardson-Olszewksi Syndrome
Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109582 ADT-OH Inducer 99.06% Unkown
HY-W027592 1H-1,2,4-Triazol-3-amine 99.96% Unkown
HY-23033 Tempone-H 99.08% Unkown
HY-157334 DEG-77 98.31% Unkown
HY-W012383 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone / Unkown
HY-103149 SB-216641A Antagonist ≥98.0% Unkown
HY-W007685 Methyl 1H-1,2,4-triazole-5-carboxylate / Unkown
HY-W012991 3-Mercapto-1,2,4-triazole 99.78% Unkown
HY-W113615 4-Phenyl-1H-1,2,3-triazole Inhibitor ≥98.0% Unkown
HY-W098127S Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate-d2 / Unkown
HY-149975 AMPA receptor modulator-4 Activator / Unkown
HY-N10765 Salvinolone Inhibitor / Unkown
HY-RS05947 H1-2 Human Pre-designed siRNA Set A / Unkown
HY-W110148S Amitrole-13C,15N2 / Unkown
HY-W329835S 2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d5 / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta H1-2 VGNC VGNC:109667
Rattus norvegicus H1-2 RGD RGD:1587893
Bos taurus H1-2 VGNC VGNC:83558
Mus musculus H1-2 MGD MGI:1931526