Tlr1 - toll-like receptor 1 Gene

Rattus norvegicus

Gene ID: 305354 | Gene type: protein coding

About Tlr1

Primary_assembly 14: 43,384,932-43,397,125 forward strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 73 orthologues, 26 paralogues and is associated with 14 phenotypes. Biased expression in Spleen (RPKM 82.1), Kidney (RPKM 4.5) and 8 other tissues.

Summary

Enables Lipopeptide binding activity. Involved in microglial cell activation; response to Bacterial lipoprotein; and Toll-like Receptor signaling pathway. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like Receptor 1-Toll-like receptor 2 protein complex. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tlr1 Products(1)

mRNA	Protein	Name
NM_001172120.2	NP_001165591.1	toll-like receptor 1 precursor

Tlr1 Protein Structure

PRK15370

LRR_1

PRK15370

LRR_RI

LRRCT

TIR

0
200
400
600
808 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 1

rCG56938-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1180A	Pam3CSK4 TFA	Agonist	99.66%	Unkown
HY-123942	Diprovocim	Agonist	98.35%	Unkown
HY-108471	CU-CPT22	Inhibitor	≥99.0%	Unkown
HY-110353	CU-T12-9	Agonist	98.94%	Unkown
HY-150501	Diprovocim-X	Agonist	98.64%	Unkown
HY-P1180	Pam3CSK4	Agonist	/	Unkown
HY-P1405	Pam3CSK4-Biotin	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr1	NCBI	NCBI:7096

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