Sphk2 - sphingosine kinase 2 Gene

Rattus norvegicus

Gene ID: 308589 | Gene type: protein coding

About Sphk2

Primary_assembly 1: 96,180,887-96,188,391 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 209 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in Kidney (RPKM 86.5), Adrenal (RPKM 75.8) and 9 other tissues.

Summary

Predicted to enable kinase activity; nucleosomal histone binding activity; and sphingosine-1-phosphate receptor activity. Involved in female pregnancy. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sphk2 Products(1)

mRNA	Protein	Name
NM_001012066.1	NP_001012066.1	sphingosine kinase 2

Sphk2 Protein Structure

PLN02958

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616 a.a.

Protein Preferred Names

Protein Names

sphingosine kinase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12892	SKI-178	Inhibitor	98.91%	Unkown
HY-147282	Amgen-23	Inhibitor	99.00%	Unkown
HY-148707	SphK1&2-IN-1	Inhibitor	99.33%	Unkown
HY-150615	SphK1-IN-2	Inhibitor	/	Unkown
HY-151350	SphK2-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sphk2	NCBI	NCBI:56848

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