HMGB2 - high mobility group box 2 Gene

Homo sapiens

Also known as HMG2

Gene ID: 3148 | Gene type: protein coding

About HMGB2

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:173,331,376-173,334,358 (from NCBI)

This gene has 5 transcripts (splice variants), 262 orthologues and 20 paralogues. Biased expression in bone marrow (RPKM 603.0), lymph node (RPKM 141.8) and 10 other tissues.

Summary

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

HMGB2 Products(3)

mRNA	Protein	Name
NM_001130688.1	NP_001124160.1	high mobility group protein B2
NM_001130689.1	NP_001124161.1	high mobility group protein B2
NM_002129.4	NP_002120.1	high mobility group protein B2

HMGB2 Protein Structure

HMG_box_2

HMG_box

0
100
209 a.a.

Protein Preferred Names

Protein Names

high mobility group protein B2

HMG-2

Recombinant HMGB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70332	HMGB2/HMG-2 Protein, Human (HEK293, His)	P26583 (G2-E209)	≥95%
HY-P700088AF	Animal-Free HMGB2/HMG-2 Protein, Human (His)	P26583 (M1-E209)	≥95%

Related Diseases

Diseases

Alias

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Autoimmune Hepatitis

Aih	Hepatitis, Autoimmune
Autoimmune Chronic Active Hepatitis	Autoimmune Hepatitis With Centrilobular Necrosis
Autoimmune Chronic Hepatitis	Hepatitis Autoimmune

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113772	Inflachromene		99.88%	Unkown
HY-RS06233	HMGB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HMGB2	MGD	MGI:96157
Canis familiaris	HMGB2	VGNC	VGNC:41710
Macaca mulatta	HMGB2	VGNC	VGNC:100234
Felis catus	HMGB2	VGNC	VGNC:82520
Rattus norvegicus	HMGB2	RGD	RGD:69291
Others	HMGB2	NCBI

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