2. Gene
  3. HNRNPD - heterogeneous nuclear ribonucleoprotein D Gene

HNRNPD - heterogeneous nuclear ribonucleoprotein D Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P37; AUF1; AUF1A; HNRPD; hnRNPD0

Gene ID: 3184 | Gene type: protein coding

About HNRNPD

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:82,352,498-82,373,991 (from NCBI)

This gene has 18 transcripts (splice variants), 198 orthologues, 36 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 80.4), bone marrow (RPKM 72.5) and 25 other tissues.

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

HNRNPD Products(4)

mRNA Protein Name
NM_001003810.2 NP_001003810.1 heterogeneous nuclear ribonucleoprotein D0 isoform d
NM_002138.4 NP_002129.2 heterogeneous nuclear ribonucleoprotein D0 isoform c
NM_031369.3 NP_112737.1 heterogeneous nuclear ribonucleoprotein D0 isoform b
NM_031370.3 NP_112738.1 heterogeneous nuclear ribonucleoprotein D0 isoform a

HNRNPD Protein Structure

CBFNT

CBFNT: CBFNT (NUC161) domain (1 - 79)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (100 - 167)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (184 - 243)

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  • 355 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein D0

ARE-binding protein AUFI, type A

Related Diseases

Diseases Alias
Ulcerative Blepharitis
Chromosome 4q21 Deletion Syndrome

4q21 Microdeletion Syndrome

Monosomy 4q21

Del(4)(Q21)

Chromosome Deletion Syndrome 4q21
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06267 HNRNPD Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HNRNPD VGNC VGNC:54954
Bos taurus HNRNPD VGNC VGNC:52786
Mus musculus HNRNPD MGD MGI:101947
Felis catus HNRNPD VGNC VGNC:67606
Rattus norvegicus HNRNPD RGD RGD:620365
Macaca mulatta HNRNPD VGNC VGNC:106590