NDST1 - N-deacetylase and N-sulfotransferase 1 Gene

Homo sapiens

Also known as HSST; NST1; MRT46

Gene ID: 3340 | Gene type: protein coding

About NDST1

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,497,779-150,558,211 (from NCBI)

This gene has 9 transcripts (splice variants), 228 orthologues, 10 paralogues and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 12.3), lung (RPKM 12.2) and 25 other tissues.

Summary

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded Enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

NDST1 Products(2)

mRNA	Protein	Name
NM_001301063.2	NP_001287992.1	bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 2
NM_001543.5	NP_001534.1	bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

NDST1 Protein Structure

HSNSD

Sulfotransfer_1

0
200
400
600
800
882 a.a.

Protein Preferred Names

Protein Names

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

HSNST 1

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 46

MRT46	Mental Retardation, Autosomal Recessive 46
Autosomal Recessive Intellectual Developmental Disorder 46	Mental Retardation, Autosomal Recessive, Type 46

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Vulto-Van Silfhout-De Vries Syndrome

Vulto-Van Silfout-De Vries Syndrome	VSVS
Intellectual Developmental Disorder With Impaired Expressive Speech And Behavioral Abnormalities, With Or Without Seizures	Iddisbas
Mrd24	Mental Retardation, Autosomal Dominant 24
Autosomal Dominant Mental Retardation 24	Autosomal Dominant Non-Syndromic Intellectual Disability 24
Mental Retardation, Autosomal Dominant, Type 24

Exostosis

Osteophyte	Exostoses
Orbital Exostosis	Exostosis Of Orbit
Bone Spur	Bony Outgrowth
Swimmer'S Exostosis	Osteophytes
External Exotoses	Cartilaginous Exostosis

Hereditary Multiple Exostoses

Multiple Congenital Exostosis	Hereditary Multiple Exostoses 1
Hereditary Multiple Exostoses 2	Hereditary Multiple Exostoses 3
Multiple Exostosis Syndromes	Multiple Ostechondromas
Osteochondromatosis Syndrome	Exostoses Multiple Hereditary
Exostoses, Multiple Hereditary

Temtamy Preaxial Brachydactyly Syndrome

Preaxial Brachydactyly Syndrome, Temtamy Type	TPBS
Intellectual Disability Syndrome With Preaxial Brachydactyly, Hyperphalangism, Deafness And Orodental Anomalies	Preaxial Brachydactyly Syndrome Temtamy Type

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia	Diaphragmatic Hernia
Cdh	Congenital Diaphragmatic Defect
Hernia, Diaphragmatic	Dih
Hernia, Congenital Diaphragmatic	Hcd
Diaphragmatic Defect, Congenital	Diaphragm, Unilateral Agenesis Of
Hemidiaphragm, Agenesis Of	Diaphragmatic Hernia 1
Agenesis Of Hemidiaphragm	Unilateral Agenesis Of Diaphragm
Hernia Diaphragmatic	Hernia Diaphragmatic Congenital
Hernia, Diaphragmatic, Type 1	Hiatus Hernia
Oesophageal Hiatus Hernia	Paraoesophageal Hernia
Sliding Hiatus Hernia	Congenital Diaphragm Hernia
Congenital Diaphragm Defect With Hernia	Gross Congenital Diaphragm Defect

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09118	NDST1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NDST1	MGD	MGI:104719
Rattus norvegicus	NDST1	RGD	RGD:69303
Felis catus	NDST1	VGNC	VGNC:68435
Bos taurus	NDST1	VGNC	VGNC:31942
Macaca mulatta	NDST1	VGNC	VGNC:75151
Canis familiaris	NDST1	VGNC	VGNC:43682

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