CLEC4G - C-type lectin domain family 4 member G Gene

Homo sapiens

Also known as LP2698; UNQ431; DTTR431; LSECtin

Gene ID: 339390 | Gene type: protein coding

About CLEC4G

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,728,957-7,732,110 (from NCBI)

This gene has 5 transcripts (splice variants), 875 orthologues and 14 paralogues. Biased expression in liver (RPKM 17.2), lymph node (RPKM 6.5) and 4 other tissues.

Summary

This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type Lectin Receptors are Pattern Recognition Receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile Filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

CLEC4G Products(2)

mRNA	Protein	Name
NM_001244856.2	NP_001231785.1	C-type lectin domain family 4 member G isoform 2
NM_198492.4	NP_940894.1	C-type lectin domain family 4 member G isoform 1

CLEC4G Protein Structure

Lectin_C

0
100
200
293 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 4 member G

C-type lectin superfamily 4, member G

Recombinant CLEC4G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78778	LSECtin/CLEC4G Protein, Human (HEK293, Fc)	Q6UXB4 (K55-C293)	≥95%

Related Diseases

Diseases

Alias

Lymphocytic Choriomeningitis

Lcm	Lymphocytic Meningitis
Lymphocytic Choriomeningitis Virus Encephalomyelitis	Lymphocytic Meningoencephalitis
Non-Arthropod Borne Lymphocytic Choriomeningitis	Lcm - [Lymphocytic Choriomeningitis]
Benign Lymphocytic Meningitis	Meningitis Due To Lymphocytic Choriomeningitis Virus

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever	Junin Hemorrhagic Fever
Hemorrhagic Fever, Argentinian	Ahf - [Argentinian Haemorrhagic Fever]
Argentine Haemorrhagic Fever	Junin Haemorrhagic Fever

Lassa Fever

Lf	Lassa Hemorrhagic Fever
Lf - [Lassa Fever]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02796	CLEC4G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLEC4G	VGNC	VGNC:27434
Canis familiaris	CLEC4G	VGNC	VGNC:39333
Felis catus	CLEC4G	VGNC	VGNC:60953
Mus musculus	CLEC4G	MGD	MGI:1923113
Rattus norvegicus	CLEC4G	RGD	RGD:1597482
Others	CLEC4G	NCBI

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