1. Gene
  2. TMC3 - transmembrane channel like 3 Gene

TMC3 - transmembrane channel like 3 Gene

Homo sapiens
Gene ID: 342125 | Gene type: protein coding

About TMC3

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:81,331,088-81,374,213 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 7 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMC3 Products(1)

mRNA Protein Name
NM_001080532.3 NP_001074001.1 transmembrane channel-like protein 3

TMC3 Protein Structure

TMC

TMC: TMC domain (499 - 614)

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  • 1100 a.a.
Protein Preferred Names Protein Names

transmembrane channel-like protein 3

Related Diseases

Diseases Alias
Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMC3 RGD RGD:1308063
Macaca mulatta TMC3 VGNC VGNC:79360
Canis familiaris TMC3 VGNC VGNC:47422
Felis catus TMC3 VGNC VGNC:80819
Mus musculus TMC3 MGD MGI:2669033
Bos taurus TMC3 VGNC VGNC:35919