TMC3 - transmembrane channel like 3 Gene

Homo sapiens

Gene ID: 342125 | Gene type: protein coding

About TMC3

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:81,331,088-81,374,213 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 7 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMC3 Products(1)

mRNA	Protein	Name
NM_001080532.3	NP_001074001.1	transmembrane channel-like protein 3

TMC3 Protein Structure

TMC

0
200
400
600
800
1000
1100 a.a.

Protein Preferred Names

Protein Names

transmembrane channel-like protein 3

Related Diseases

Diseases

Alias

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14623	TMC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMC3	RGD	RGD:1308063
Macaca mulatta	TMC3	VGNC	VGNC:79360
Canis familiaris	TMC3	VGNC	VGNC:47422
Felis catus	TMC3	VGNC	VGNC:80819
Mus musculus	TMC3	MGD	MGI:2669033
Bos taurus	TMC3	VGNC	VGNC:35919

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