2. Gene
  3. IMPA1 - inositol monophosphatase 1 Gene

IMPA1 - inositol monophosphatase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IMP; IMPA; MRT59

Gene ID: 3612 | Gene type: protein coding

About IMPA1

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,656,914-81,686,325 (from NCBI)

This gene has 13 transcripts (splice variants), 232 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 15.5), thyroid (RPKM 10.4) and 24 other tissues.

Summary

This gene encodes an Enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This Enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This Enzyme shows magnesium-dependent Phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]

IMPA1 Products(3)

mRNA Protein Name
NM_001144878.2 NP_001138350.1 inositol monophosphatase 1 isoform 2
NM_001144879.2 NP_001138351.1 inositol monophosphatase 1 isoform 3
NM_005536.4 NP_005527.1 inositol monophosphatase 1 isoform 1

IMPA1 Protein Structure

Inositol_P

Inositol_P: Inositol monophosphatase family (7 - 267)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

inositol monophosphatase 1

D-galactose 1-phosphate phosphatase

Recombinant IMPA1 Proteins

Cat. No. Product Name Accession Purity
HY-P70335 IMPA1 Protein, Human (His) P29218 (M1-D277) ≥95%

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Recessive 59

MRT59

Mental Retardation, Autosomal Recessive 59

Autosomal Recessive Intellectual Developmental Disorder 59
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Mood Disorder

Mood Disorders

Episodic Mood Disorder
Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome

SPOAN

Spastic Paraplegia, Optic Atropy, And Neuropathy

Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome

Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Developmental And Epileptic Encephalopathy 11

Epileptic Encephalopathy, Early Infantile, 11

DEE11

Eiee11

Developmental And Epileptic Encephalopathy, 11

Early Infantile Epileptic Encephalopathy 11

Encephalopathy, Developmental And Epileptic, Type 11
Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy

Familial Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy 1

CMH1

Hypertrophic Cardiomyopathy 19

CMH

Ventricular Hypertrophy, Hereditary

Ash

Hypertrophic Subaortic Stenosis, Idiopathic

Cardiomyopathy, Familial Hypertrophic

Cardiomyopathy, Hypertrophic, 1, Digenic

Cardiomyopathy, Familial Hypertrophic 1

Hcm

Hereditary Ventricular Hypertrophy

Idiopathic Hypertrophic Subaortic Stenosis

Hypertrophic Cardiomyopathy

Cardiomyopathy, Hypertrophic, Familial

Cardiomyopathy, Hypertrophic, 1

Familial Asymmetric Septal Hypertrophy

Heritable Hypertrophic Cardiomyopathy

Fhc

Cardiomyopathy, Hypertrophic, Familial, Type 1
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125053A Batifiban TFA Antagonist 99.58% Unkown
HY-P1390 d[Cha4]-AVP Agonist 99.27% Unkown
HY-P10046 [Deamino-Pen1,Val4,D-Arg8]-vasopressin Inhibitor / Unkown
HY-P4397 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin / Unkown
HY-P5006 (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin Antagonist / Unkown
HY-RS06795 IMPA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-125053 Batifiban / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IMPA1 VGNC VGNC:42007
Bos taurus IMPA1 VGNC VGNC:30184
Mus musculus IMPA1 MGD MGI:1933158
Macaca mulatta IMPA1 VGNC VGNC:84008
Rattus norvegicus IMPA1 RGD RGD:69254
Felis catus IMPA1 VGNC VGNC:67796
Others IMPA1 NCBI