ITGB5 - integrin subunit beta 5 Gene

Homo sapiens

Gene ID: 3693 | Gene type: protein coding

About ITGB5

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:124,761,948-124,901,418 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 40.4), gall bladder (RPKM 34.0) and 24 other tissues.

Summary

This gene encodes a beta subunit of Integrin, which can combine with different alpha chains to form a variety of Integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 Integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]

ITGB5 Products(4)

mRNA	Protein	Name
NM_001354764.2	NP_001341693.1	integrin beta-5 isoform b
NM_001354765.1	NP_001341694.1	integrin beta-5 isoform b
NM_001354766.2	NP_001341695.1	integrin beta-5 isoform c
NM_002213.5	NP_002204.2	integrin beta-5 isoform a precursor

ITGB5 Protein Structure

Integrin_beta

Integrin_B_tail

Integrin_b_cyt

0
200
400
600
799 a.a.

Protein Preferred Names

Protein Names

integrin beta-5

testis secretory sperm-binding protein Li 217p

Recombinant ITGB5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77720	Integrin alpha V beta 5 Protein, Human (HEK293, His-Avi)	P06756 (F31-V992)&P18084 (G24-N719)	≥95%

Related Diseases

Diseases

Alias

Villous Adenocarcinoma

Osteopetrosis, Autosomal Dominant 2

OPTA2	Autosomal Dominant Osteopetrosis 2
Osteopetrosis Autosomal Dominant Type 2	Osteopetrosis, Autosomal Dominant, Type Ii
Albers-Schonberg Osteopetrosis	Autosomal Dominant Albers-Schonberg Disease
Osteopetrosis	Marble Bones, Autosomal Dominant
Osteosclerosis Fragilis Generalisata	Albers-Schonberg Disease, Autosomal Dominant
Autosomal Dominant Osteopetrosis Type Ii	Albers-Schönberg Osteopetrosis
Autosomal Dominant Osteopetrosis Type 2	Marble Disease Autosomal Dominant
Osteopetrosis, Autosomal Dominant, Type 2

Luminal Breast Carcinoma A

Breast Tumor Luminal	Luminal A Breast Carcinoma
Luminal Breast Cancer

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06969	ITGB5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ITGB5	VGNC	VGNC:73788
Canis familiaris	ITGB5	VGNC	VGNC:42140
Felis catus	ITGB5	VGNC	VGNC:67854
Bos taurus	ITGB5	VGNC	VGNC:30330
Rattus norvegicus	ITGB5	RGD	RGD:628869
Mus musculus	ITGB5	MGD	MGI:96614
Others	ITGB5	NCBI

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