KPNA1 - karyopherin subunit alpha 1 Gene

Homo sapiens

Also known as RCH2; SRP1; IPOA5; NPI-1

Gene ID: 3836 | Gene type: protein coding

About KPNA1

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,421,902-122,514,939 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.0), testis (RPKM 7.9) and 25 other tissues.

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

KPNA1 Products(1)

mRNA	Protein	Name
NM_002264.4	NP_002255.3	importin subunit alpha-5

KPNA1 Protein Structure

IBB

Arm

0
100
200
300
400
500
538 a.a.

Protein Preferred Names

Protein Names

importin subunit alpha-5

RAG cohort protein 2

Related Diseases

Diseases

Alias

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Plica Syndrome

Synovitis

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07415	KPNA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KPNA1	RGD	RGD:735064
Felis catus	KPNA1	VGNC	VGNC:102766
Mus musculus	KPNA1	MGD	MGI:103560
Bos taurus	KPNA1	VGNC	VGNC:30700
Macaca mulatta	KPNA1	VGNC	VGNC:74199
Canis familiaris	KPNA1	VGNC	VGNC:42500

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