2. Gene
  3. TRIM37 - tripartite motif containing 37 Gene

TRIM37 - tripartite motif containing 37 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MUL; POB1; TEF3

Gene ID: 4591 | Gene type: protein coding

About TRIM37

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,967,201-59,106,880 (from NCBI)

This gene has 14 transcripts (splice variants), 206 orthologues, 80 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]

TRIM37 Products(11)

mRNA Protein Name
NM_001005207.5 NP_001005207.1 E3 ubiquitin-protein ligase TRIM37 isoform a
NM_001320987.3 NP_001307916.1 E3 ubiquitin-protein ligase TRIM37 isoform b
NM_001320988.3 NP_001307917.1 E3 ubiquitin-protein ligase TRIM37 isoform c
NM_001320989.3 NP_001307918.1 E3 ubiquitin-protein ligase TRIM37 isoform c
NM_001320990.3 NP_001307919.1 E3 ubiquitin-protein ligase TRIM37 isoform d
NM_001353082.2 NP_001340011.1 E3 ubiquitin-protein ligase TRIM37 isoform e
NM_001353083.2 NP_001340012.1 E3 ubiquitin-protein ligase TRIM37 isoform f
NM_001353084.2 NP_001340013.1 E3 ubiquitin-protein ligase TRIM37 isoform g
NM_001353085.2 NP_001340014.1 E3 ubiquitin-protein ligase TRIM37 isoform h
NM_001353086.2 NP_001340015.1 E3 ubiquitin-protein ligase TRIM37 isoform i
NM_015294.6 NP_056109.1 E3 ubiquitin-protein ligase TRIM37 isoform a

TRIM37 Protein Structure

zf-B_box

zf-B_box: B-box zinc finger (91 - 132)

MATH

MATH: MATH domain (284 - 403)

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  • 964 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM37

RING-B-box-coiled-coil protein

Related Diseases

Diseases Alias
Mulibrey Nanism

MUL

Muscle-Liver-Brain-Eye Nanism

Pericardial Constriction And Growth Failure

Perheentupa Syndrome

Mulibrey Growth Disorder

Mulibrey Nanism Syndrome

Pericardial Constriction With Growth Failure

Nanism Mulibrey
Acid-Labile Subunit Deficiency

Short Stature Due To Primary Acid-Labile Subunit Deficiency

ACLSD

Acid-Labile Subunit, Deficiency Of

Decreased Levels Of Acid Labile Subunit

Growth Disorders
Peroxisomal Disease

Peroxisomal Disorder

Peroxisomal Disorders

Peroxisomal Defects
Constrictive Pericarditis

Pericarditis, Constrictive

Pericarditis Constrictive

Pericarditis Calculosa

Hutinel-Pick Syndrome

Chronic Tamponade

Chronic Pericardial Constriction

Pick Syndrome Of Heart

Pick Disease Of Heart

Concretio Cordis

Calcareous Pericarditis
Childhood Osteosarcoma

Pediatric Osteosarcoma
Three M Syndrome 1

3-M Syndrome

Yakut Short Stature Syndrome

3m Syndrome

Le Merrer Syndrome

Dolichospondylic Dysplasia

Gloomy Face Syndrome

Three M Syndrome

3M1

3m Syndrome 1

Miller-Mckusick-Malvaux Syndrome

3-Msbn

Three-M Slender-Boned Nanism

Miller-Mckusick-Malvaux-Syndrome

3-M Syndrome 1

3m Syndrome-1

3m Syndrome, Type 1

Dwarfism

Dwarfism Tall Vertebrae
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders

Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

Disorders Of Peroxisome Biogenesis

Zellweger Spectrum

Zellweger Syndrome Spectrum

Peroxisomal Biogenesis Disorders

Pbd, Zss

Pbd-Zsd

Pbd-Zss

Pbd-Zellweger Spectrum Disorder

Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum

Peroxisome Biogenesis Disorder

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorders

Zellweger Spectrum Disorder

Hyperpipecolic Acidaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15041 TRIM37 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TRIM37 RGD RGD:1308349
Bos taurus TRIM37 VGNC VGNC:36332
Mus musculus TRIM37 MGD MGI:2153072
Macaca mulatta TRIM37 VGNC VGNC:79966
Felis catus TRIM37 VGNC VGNC:68360
Canis familiaris TRIM37 VGNC VGNC:47818