2. Gene
  3. NDUFB2 - NADH:ubiquinone oxidoreductase subunit B2 Gene

NDUFB2 - NADH:ubiquinone oxidoreductase subunit B2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AGGG; CI-AGGG

Gene ID: 4708 | Gene type: protein coding

About NDUFB2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,696,708-140,706,643 (from NCBI)

This gene has 15 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in heart (RPKM 93.9), kidney (RPKM 78.0) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the Enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]

NDUFB2 Products(1)

mRNA Protein Name
NM_004546.3 NP_004537.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor

NDUFB2 Protein Structure

NADH_B2

NADH_B2: NADH dehydrogenase 1 beta subcomplex subunit 2 (35 - 105)

  • 0
  • 105 a.a.
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa

Related Diseases

Diseases Alias
Intraneural Perineurioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09147 NDUFB2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NDUFB2 VGNC VGNC:43701
Macaca mulatta NDUFB2 VGNC VGNC:75156
Rattus norvegicus NDUFB2 RGD RGD:1308130
Mus musculus NDUFB2 MGD MGI:1915448
Felis catus NDUFB2 VGNC VGNC:80634
Bos taurus NDUFB2 VGNC VGNC:31962