2. Gene
  3. NOVA1 - NOVA alternative splicing regulator 1 Gene

NOVA1 - NOVA alternative splicing regulator 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Nova-1

Gene ID: 4857 | Gene type: protein coding

About NOVA1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:26,443,090-26,598,033 (from NCBI)

This gene has 13 transcripts (splice variants), 295 orthologues and 12 paralogues. Biased expression in brain (RPKM 10.5), fat (RPKM 4.3) and 12 other tissues.

Summary

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic Antibodies. These Antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast Cancer, and small cell lung Cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

NOVA1 Products(12)

mRNA Protein Name
NM_001366390.2 NP_001353319.1 RNA-binding protein Nova-1 isoform 4
NM_001366391.2 NP_001353320.1 RNA-binding protein Nova-1 isoform 5
NM_001366392.2 NP_001353321.1 RNA-binding protein Nova-1 isoform 6
NM_001366393.2 NP_001353322.1 RNA-binding protein Nova-1 isoform 7
NM_001366394.2 NP_001353323.1 RNA-binding protein Nova-1 isoform 8
NM_001366395.2 NP_001353324.1 RNA-binding protein Nova-1 isoform 5
NM_001366396.2 NP_001353325.1 RNA-binding protein Nova-1 isoform 5
NM_001366397.2 NP_001353326.1 RNA-binding protein Nova-1 isoform 4
NM_001366398.2 NP_001353327.1 RNA-binding protein Nova-1 isoform 5
NM_002515.3 NP_002506.2 RNA-binding protein Nova-1 isoform 1
NM_006489.3 NP_006480.2 RNA-binding protein Nova-1 isoform 2
NM_006491.3 NP_006482.1 RNA-binding protein Nova-1 isoform 3

NOVA1 Protein Structure

KH_1

KH_1: KH domain (53 - 111)

KH_1

KH_1: KH domain (174 - 237)

KH_1

KH_1: KH domain (424 - 488)

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  • 507 a.a.
Protein Preferred Names Protein Names

RNA-binding protein Nova-1

neuro-oncological ventral antigen 1

Related Diseases

Diseases Alias
Myoclonus
Cutaneous Adenocystic Carcinoma

Adenoid Cystic Eccrine Carcinoma

Adenoid Cystic Carcinoma Of The Skin

Adenoid Cystic Eccrine Carcinoma Of Skin
Partial Fetal Alcohol Syndrome
Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09455 NOVA1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NOVA1 RGD RGD:621345
Bos taurus NOVA1 VGNC VGNC:84869
Macaca mulatta NOVA1 VGNC VGNC:75373
Felis catus NOVA1 VGNC VGNC:68521
Canis familiaris NOVA1 VGNC VGNC:43902
Mus musculus NOVA1 MGD MGI:104297