2. Gene
  3. NPY5R - neuropeptide Y receptor Y5 Gene

NPY5R - neuropeptide Y receptor Y5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NPYR5; NPY5-R; NPYY5-R

Gene ID: 4889 | Gene type: protein coding

About NPY5R

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,343,892-163,352,403 (from NCBI)

This gene has 3 transcripts (splice variants), 137 orthologues and 33 paralogues. Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues.

Summary

The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

NPY5R Products(3)

mRNA Protein Name
NM_001317091.2 NP_001304020.1 neuropeptide Y receptor type 5
NM_001317092.2 NP_001304021.1 neuropeptide Y receptor type 5
NM_006174.4 NP_006165.1 neuropeptide Y receptor type 5

NPY5R Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 425)

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  • 445 a.a.
Protein Preferred Names Protein Names

neuropeptide Y receptor type 5

NPY-Y5 receptor

Related Diseases

Diseases Alias
Dihydropyrimidinase Deficiency

Dihydropyrimidinuria

Dpys Deficiency

Dph Deficiency

DPYSD

Dihydrouracil Amidohydrolase Deficiency

Dihydropyrimidinuria Due To Dpys Deficiency
Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107734 L 152804 Antagonist 99.48% Unkown
HY-RS09520 NPY5R Human Pre-designed siRNA Set A / Unkown
HY-RS09521 Npy5r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09522 Npy5r Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NPY5R VGNC VGNC:54273
Mus musculus NPY5R MGD MGI:108082
Bos taurus NPY5R VGNC VGNC:32224
Rattus norvegicus NPY5R RGD RGD:3199
Felis catus NPY5R VGNC VGNC:68539
Macaca mulatta NPY5R VGNC VGNC:75395