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  3. P2RX4 - purinergic receptor P2X 4 Gene

P2RX4 - purinergic receptor P2X 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P2X4; P2X4R

Gene ID: 5025 | Gene type: protein coding

About P2RX4

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,210,129-121,234,106 (from NCBI)

This gene has 13 transcripts (splice variants), 211 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 18.6), colon (RPKM 15.4) and 25 other tissues.

Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

P2RX4 Products(11)

mRNA Protein Name
NM_001261397.2 NP_001248326.1 P2X purinoceptor 4 isoform 3
XM_047428911.1 XP_047284867.1 P2X purinoceptor 4 isoform X3
NR_046372.2
XM_011538416.3 XP_011536718.1 P2X purinoceptor 4 isoform X2
XM_047428910.1 XP_047284866.1 P2X purinoceptor 4 isoform X1
NM_001261398.2 NP_001248327.1 P2X purinoceptor 4 isoform 4
NR_046373.2
NM_175568.1
NM_175567.1
NM_001256796.2 NP_001243725.1 P2X purinoceptor 4 isoform 1
NM_002560.3 NP_002551.2 P2X purinoceptor 4 isoform 2

P2RX4 Protein Structure

P2X_receptor

P2X_receptor: ATP P2X receptor (13 - 385)

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  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 4

ATP receptor

ATP-gated cation channel protein

P2X receptor, subunit 4

purinergic receptor P2X, ligand gated ion channel, 4

purinergic receptor P2X4

purinoceptor P2X4

Related Diseases

Diseases Alias
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Paine Syndrome

Pain Disorder

Pain

Microcephaly With Spastic Diplegia

Pain Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09906 P2RX4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09907 P2rx4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09908 P2rx4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus P2RX4 VGNC VGNC:68671
Canis familiaris P2RX4 VGNC VGNC:44210
Mus musculus P2RX4 MGD MGI:1338859
Macaca mulatta P2RX4 VGNC VGNC:75734
Rattus norvegicus P2RX4 RGD RGD:62073
Bos taurus P2RX4 VGNC VGNC:32520