PCDH1 - protocadherin 1 Gene

Homo sapiens

Also known as PC42; PCDH42

Gene ID: 5097 | Gene type: protein coding

About PCDH1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,853,090-141,878,410 (from NCBI)

This gene has 8 transcripts (splice variants), 274 orthologues and 33 paralogues. Ubiquitous expression in brain (RPKM 10.0), colon (RPKM 8.9) and 22 other tissues.

Summary

This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008]

PCDH1 Products(4)

mRNA	Protein	Name
NM_001278613.2	NP_001265542.1	protocadherin-1 isoform 3
NM_001278615.1	NP_001265544.1	protocadherin-1 isoform 4
NM_002587.5	NP_002578.2	protocadherin-1 isoform 1 precursor
NM_032420.5	NP_115796.2	protocadherin-1 isoform 2 precursor

PCDH1 Protein Structure

Cadherin_2

Cadherin

Protocadherin

0
200
400
600
800
1000
1060 a.a.

Protein Preferred Names

Protein Names

protocadherin-1

cadherin-like 1

Recombinant PCDH1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71187	PCDH1 Protein, Human (HEK293, His)	Q08174 (T58-N852)	≥95%

Related Diseases

Diseases

Alias

Esophageal Atresia

Tracheoesophageal Fistula	Congenital Atresia Of Esophagus
Congenital Imperforate Esophagus	Imperforate Esophagus
Oesophageal Atresia	Te Fistula
Tef	Tracheoesophageal Fistula With Or Without Esophageal Atresia

Hantavirus Pulmonary Syndrome

Hps	Four Corners Hantavirus
Hards	Hantavirus
Hantavirus-Associated Respiratory Distress Syndrome	Hanta Virus
Hantavirus Cardiopulmonary Syndrome	Hps - [Hantavirus Pulmonary Syndrome]
Hcps - [Hantavirus Cardiopulmonary Syndrome]

Hantavirus Hemorrhagic Fever With Renal Syndrome

Hemorrhagic Fever, Russian	Hemorrhagic Nephrosonephritis
Hfrs	Puumala Virus Nephropathy
Hemorrhagic Fever With Renal Syndrome

Esophageal Atresia/Tracheoesophageal Fistula

Esophageal Atresia And/Or Tracheoesophageal Fistula	Tracheoesophageal Fistula With Or Without Esohageal Atresia
Esophageal Atresia / Tracheoesophageal Fistula	Ea/Tef
Esophageal Atresia With Tracheoesophageal Fistula	Esophageal Atresia With Or Without Tracheoesophageal Fistula

Corneal Dystrophy, Endothelial, X-Linked

X-Linked Endothelial Corneal Dystrophy	XECD
Endothelial Corneal Dystrophy, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10121	PCDH1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCDH1	RGD	RGD:1308490
Canis familiaris	PCDH1	VGNC	VGNC:44294
Bos taurus	PCDH1	VGNC	VGNC:32615
Felis catus	PCDH1	VGNC	VGNC:68715
Macaca mulatta	PCDH1	VGNC	VGNC:75775
Mus musculus	PCDH1	MGD	MGI:104692
Others	PCDH1	NCBI

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