CRIM1 - cysteine rich transmembrane BMP regulator 1 Gene

Homo sapiens

Also known as S52; CRIM-1

Gene ID: 51232 | Gene type: protein coding

About CRIM1

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,355,778-36,551,135 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 133 orthologues, 19 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 93.7), fat (RPKM 55.7) and 23 other tissues.

Summary

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

CRIM1 Products(1)

mRNA	Protein	Name
NM_016441.3	NP_057525.1	cysteine-rich motor neuron 1 protein precursor

CRIM1 Protein Structure

VWC

Antistasin

VWC

0
200
400
600
800
1036 a.a.

Protein Preferred Names

Protein Names

cysteine-rich motor neuron 1 protein

cysteine rich transmembrane BMP regulator 1 (chordin-like)

Related Diseases

Diseases

Alias

Macrophthalmia, Colobomatous, With Microcornea

MACOM	Colobomatous Macrophthalmia-Microcornea Syndrome
Macom Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03174	CRIM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRIM1	VGNC	VGNC:27710
Mus musculus	CRIM1	MGD	MGI:1354756
Felis catus	CRIM1	VGNC	VGNC:61178
Canis familiaris	CRIM1	VGNC	VGNC:39612
Macaca mulatta	CRIM1	VGNC	VGNC:106144
Rattus norvegicus	CRIM1	RGD	RGD:1308710

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