UBAP1 - ubiquitin associated protein 1 Gene

Homo sapiens

Also known as UAP; UBAP; NAG20; SPG80; UBAP-1

Gene ID: 51271 | Gene type: protein coding

About UBAP1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,179,005-34,252,523 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 39.6), testis (RPKM 26.3) and 25 other tissues.

Summary

This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

UBAP1 Products(5)

mRNA	Protein	Name
NM_001171201.1	NP_001164672.1	ubiquitin-associated protein 1 isoform 2
NM_001171202.1	NP_001164673.1	ubiquitin-associated protein 1 isoform 3
NM_001171203.3	NP_001164674.1	ubiquitin-associated protein 1 isoform 1
NM_001171204.3	NP_001164675.1	ubiquitin-associated protein 1 isoform 1
NM_016525.5	NP_057609.2	ubiquitin-associated protein 1 isoform 1

Protein Preferred Names

Protein Names

ubiquitin-associated protein 1

nasopharyngeal carcinoma-associated gene 20 protein

Recombinant UBAP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71396	UBAP1 Protein, Human (His)	Q9NZ09 (M1-S502)	≥95%

Related Diseases

Diseases

Alias

Spastic Paraplegia 80, Autosomal Dominant

SPG80	Hereditary Spastic Paraplegia 80
Spastic Paraplegia 80 Autosomal Dominant	Doid:0112341

Spastic Paraplegia 12, Autosomal Dominant

SPG12	Hereditary Spastic Paraplegia 12
Autosomal Dominant Spastic Paraplegia Type 12	Autosomal Dominant Spastic Paraplegia 12
Spastic Paraplegia 12	Spastic Paraplegia-12
Paraplegia, Spastic, Autosomal Dominant, Type 12

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Paraplegia

Paraplegia, Lower

Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk

Spastic Paraplegia 83, Autosomal Recessive

SPG83	Hereditary Spastic Paraplegia 83
Spastic Paraplegia 83 Autosomal Recessive	Doid:0112346
Paraplegia, Spastic, Type 83, Autosomal Recessive

Spastic Paraplegia 81, Autosomal Recessive

SPG81	Autosomal Recessive Complex Spastic Paraplegia Due To Kennedy Pathway Dysfunction
Autosomal Recessive Complex Spg Due To Kennedy Pathway Dysfunction	Hereditary Spastic Paraplegia 81
Spastic Paraplegia 81 Autosomal Recessive	Doid:0112349

Spastic Paraplegia 82, Autosomal Recessive

SPG82	Hereditary Spastic Paraplegia 82
Spastic Paraplegia 82 Autosomal Recessive	Doid:0112343

Spastic Paraplegia 79, Autosomal Recessive

Early-Onset Progressive Neurodegeneration-Blindness-Ataxia-Spasticity Syndrome	SPG79
Neurodegeneration With Optic Atrophy, Childhood-Onset	Ndgoa
Hereditary Spastic Paraplegia 79	Spastic Paraplegia 79 Autosomal Recessive
Doid:0112344	Neurodegeneration, With Optic Atrophy, Childhood-Onset

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15328	UBAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBAP1	MGD	MGI:2149543
Felis catus	UBAP1	VGNC	VGNC:97677
Bos taurus	UBAP1	VGNC	VGNC:36571
Macaca mulatta	UBAP1	VGNC	VGNC:78686
Rattus norvegicus	UBAP1	RGD	RGD:1305186
Others	UBAP1	NCBI

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