2. Gene
  3. NRN1 - neuritin 1 Gene

NRN1 - neuritin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NRN; dJ380B8.2

Gene ID: 51299 | Gene type: protein coding

About NRN1

Cytogenetic location: 6p25.1 Genomic coordinates (GRCh38): 6:5,997,999-6,007,518 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 1 paralogue. Broad expression in brain (RPKM 29.3), fat (RPKM 22.7) and 14 other tissues.

Summary

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

NRN1 Products(3)

mRNA Protein Name
NM_001278710.2 NP_001265639.1 neuritin isoform 1 precursor
NM_001278711.2 NP_001265640.1 neuritin isoform 2
NM_016588.3 NP_057672.1 neuritin isoform 1 precursor

NRN1 Protein Structure

NRN1

NRN1: Neuritin protein family (31 - 118)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

neuritin

Recombinant NRN1 Proteins

Cat. No. Product Name Accession Purity
HY-P70920 Neuritin Protein, Human (His) Q9NPD7 (A28-G116) ≥95%
HY-P71908 Neuritin Protein, Human Q9NPD7 (A28-N115) ≥95%
HY-P71908A Neuritin Protein, Human (N-His) Q9NPD7 (A28-N115) ≥95%

Related Diseases

Diseases Alias
Severe Congenital Neutropenia 8

Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities

Scn8

Sdsl

Shwachman-Diamond Syndrome-Like
Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease

SMA1

Spinal Muscular Atrophy 1

Sma I

Sma, Infantile Acute Form

Muscular Atrophy, Infantile

Spinal Muscular Atrophy-1

Hmn Proximal Type I

Infantile Muscular Atrophy

Proximal Spinal Muscular Atrophy Type 1

Sma Type 1

Sma Type I

Sma-I

Hereditary Motor Neuropathy Proximal Type I

Progressive Muscular Atrophy Of Infancy

Proximal Spinal Muscular Atrophy, Type 1

Werdnig Hoffmann Disease

Infantile Spinal Muscular Atrophy

Infantile-Onset Spinal Muscular Atrophy

Proximal Hereditary Motor Neuropathy Type I

Sma Infantile Acute Form

Spinal Muscular Atrophy Type I

Werdnig-Hoffman Disease

Atrophy, Muscular, Spinal, Type 1
Spinal Muscular Atrophy, Type Iii

SMA3

Juvenile Spinal Muscular Atrophy

Kugelberg-Welander Disease

Sma Iii

Kugelberg-Welander Syndrome

Kws

Muscular Atrophy, Juvenile

Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

Spinal Muscular Atrophy-3

Spinal Muscular Atrophy Type 3

Spinal Muscular Atrophy, Type Iii, Modifier Of

Type Iii Spinal Muscular Atrophy

Sma 3

Proximal Spinal Muscular Atrophy Type 3

Sma Type 3

Sma Type Iii

Sma-Iii

Spinal Muscular Atrophy 3

Spinal Muscular Atrophy Mild Childhood And Adolescent Form

Spinal Muscular Atrophy Type Iii

Wohlfart-Kugelberg-Welander Disease

Atrophy, Muscular, Spinal, Type Iii
Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09577 NRN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09578 NRN1L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NRN1 VGNC VGNC:32265
Canis familiaris NRN1 VGNC VGNC:43973
Felis catus NRN1 VGNC VGNC:63881
Rattus norvegicus NRN1 RGD RGD:621586
Macaca mulatta NRN1 VGNC VGNC:104417
Mus musculus NRN1 MGD MGI:1915654
Others NRN1 NCBI