TNFRSF12A - TNF receptor superfamily member 12A Gene

Homo sapiens

Also known as FN14; CD266; TWEAKR

Gene ID: 51330 | Gene type: protein coding

About TNFRSF12A

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,020,368-3,022,383 (from NCBI)

This gene has 7 transcripts (splice variants) and 88 orthologues. Ubiquitous expression in gall bladder (RPKM 21.3), liver (RPKM 18.8) and 23 other tissues.

Summary

Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TNFRSF12A Products(1)

mRNA	Protein	Name
NM_016639.3	NP_057723.1	tumor necrosis factor receptor superfamily member 12A precursor

TNFRSF12A Protein Structure

stn_TNFRSF12A

0
100
129 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 12A

FGF-inducible 14

Recombinant TNFRSF12A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71909	TNFRSF12A Protein, Human	Q9NP84 (E28-P80)	≥95%
HY-P72434	TNFRSF12A Protein, Human (HEK293, Fc)	Q9NP84 (E28-W79)	≥95%

Related Diseases

Diseases

Alias

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99361	Enavatuzumab	Inhibitor	≥95.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14803	TNFRSF12A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TNFRSF12A	VGNC	VGNC:47656
Bos taurus	TNFRSF12A	VGNC	VGNC:36162
Mus musculus	TNFRSF12A	MGD	MGI:1351484
Macaca mulatta	TNFRSF12A	VGNC	VGNC:99623
Rattus norvegicus	TNFRSF12A	RGD	RGD:631329
Felis catus	TNFRSF12A	VGNC	VGNC:107825
Others	TNFRSF12A	NCBI

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