PLA1A - phospholipase A1 member A Gene

Homo sapiens

Also known as PSPLA1; PS-PLA1

Gene ID: 51365 | Gene type: protein coding

About PLA1A

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:119,597,885-119,629,811 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 9 paralogues. Broad expression in liver (RPKM 8.5), lymph node (RPKM 6.1) and 17 other tissues.

Summary

The protein encoded by this gene is a Phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

PLA1A Products(4)

mRNA	Protein	Name
NM_001206960.2	NP_001193889.1	phospholipase A1 member A isoform 2 precursor
NM_001206961.2	NP_001193890.1	phospholipase A1 member A isoform 3
NM_001293225.2	NP_001280154.1	phospholipase A1 member A isoform 4
NM_015900.4	NP_056984.1	phospholipase A1 member A isoform 1 precursor

PLA1A Protein Structure

Lipase

0
100
200
300
400
456 a.a.

Protein Preferred Names

Protein Names

phospholipase A1 member A

phosphatidylserine-specific phospholipase A1alpha

Related Diseases

Diseases

Alias

Orofacial Cleft 8

OFC8	Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8
Non-Syndromic Cleft Lip/Palate 8	Non-Syndromic Cleft Lip With Or Without Cleft Palate 8
Orofacial Cleft, Type 8

Powassan Encephalitis

Powassan Encephalitis Virus Infection

Familial Woolly Hair Syndrome

Wooly Hair	Familial Wooly Hair Syndrome
Hereditary Woolly Hair Syndrome	Hereditary Wooly Hair Syndrome
Woolly Hair	Syndrome With Woolly Hair
Wooly Hair Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10615	PLA1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLA1A	RGD	RGD:621261
Bos taurus	PLA1A	VGNC	VGNC:32953
Canis familiaris	PLA1A	VGNC	VGNC:44619
Macaca mulatta	PLA1A	VGNC	VGNC:76051
Mus musculus	PLA1A	MGD	MGI:1934677

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