AMOTL2 - angiomotin like 2 Gene

Homo sapiens

Also known as LCCP

Gene ID: 51421 | Gene type: protein coding

About AMOTL2

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,355,345-134,375,417 (from NCBI)

This gene has 13 transcripts (splice variants), 267 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 33.7), placenta (RPKM 20.8) and 24 other tissues.

Summary

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

AMOTL2 Products(4)

mRNA	Protein	Name
NM_001278683.1	NP_001265612.1	angiomotin-like protein 2 isoform 1
NM_001278685.2	NP_001265614.1	angiomotin-like protein 2 isoform 3
NM_001363943.2	NP_001350872.1	angiomotin-like protein 2 isoform 4
NM_016201.4	NP_057285.3	angiomotin-like protein 2 isoform 2

AMOTL2 Protein Structure

Angiomotin_C

0
200
400
600
779 a.a.

Protein Preferred Names

Protein Names

angiomotin-like protein 2

Leman coiled-coil protein

Related Diseases

Diseases

Alias

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00665	AMOTL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AMOTL2	VGNC	VGNC:37837
Rattus norvegicus	AMOTL2	RGD	RGD:70977
Bos taurus	AMOTL2	VGNC	VGNC:25872
Felis catus	AMOTL2	VGNC	VGNC:59771
Mus musculus	AMOTL2	MGD	MGI:1929286

Name
Email *

	Sorry, but the email address you supplied was invalid.