PHF7 - PHD finger protein 7 Gene

Homo sapiens

Also known as HSPC045; HSPC226; NYD-SP6

Gene ID: 51533 | Gene type: protein coding

About PHF7

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,410,660-52,423,641 (from NCBI)

This gene has 10 transcripts (splice variants), 213 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 610.5).

Summary

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

PHF7 Products(4)

mRNA	Protein	Name
NM_001278221.3	NP_001265150.1	PHD finger protein 7 isoform 2
NM_001321126.2	NP_001308055.1	PHD finger protein 7 isoform 1
NM_001321127.2	NP_001308056.1	PHD finger protein 7 isoform 1
NM_016483.7	NP_057567.3	PHD finger protein 7 isoform 1

PHF7 Protein Structure

zf-HC5HC2H

0
100
200
300
381 a.a.

Protein Preferred Names

Protein Names

PHD finger protein 7

testicular secretory protein Li 34

Related Diseases

Diseases

Alias

Granulomatous Orchitis

Non-Specific Granulomatous Orchitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10430	PHF7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PHF7	RGD	RGD:1308638
Felis catus	PHF7	VGNC	VGNC:64146
Bos taurus	PHF7	VGNC	VGNC:32827
Canis familiaris	PHF7	VGNC	VGNC:44493
Mus musculus	PHF7	MGD	MGI:1919088
Macaca mulatta	PHF7	VGNC	VGNC:75828