2. Gene
  3. PLP2 - proteolipid protein 2 Gene

PLP2 - proteolipid protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as A4; A4LSB

Gene ID: 5355 | Gene type: protein coding

About PLP2

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:49,171,898-49,175,235 (from NCBI)

This gene has 2 transcripts (splice variants), 233 orthologues and 14 paralogues. Ubiquitous expression in skin (RPKM 154.7), esophagus (RPKM 126.0) and 23 other tissues.

Summary

This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

PLP2 Products(1)

mRNA Protein Name
NM_002668.3 NP_002659.1 proteolipid protein 2

PLP2 Protein Structure

MARVEL

MARVEL: Membrane-associating domain (21 - 130)

  • 0
  • 100
  • 152 a.a.
Protein Preferred Names Protein Names

proteolipid protein 2

A4 differentiation-dependent protein

Related Diseases

Diseases Alias
Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos
Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P2296 Abz-FRLKGGAPIKGV-EDDNP TFA / Unkown
HY-RS10732 PLP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLP2 VGNC VGNC:56949
Mus musculus PLP2 MGD MGI:1298382
Felis catus PLP2 VGNC VGNC:101462
Rattus norvegicus PLP2 RGD RGD:1587363
Macaca mulatta PLP2 VGNC VGNC:76179