2. Gene
  3. PLSCR1 - phospholipid scramblase 1 Gene

PLSCR1 - phospholipid scramblase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MMTRA1B

Gene ID: 5359 | Gene type: protein coding

About PLSCR1

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:146,515,180-146,544,607 (from NCBI)

This gene has 19 transcripts (splice variants), 235 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 43.5), gall bladder (RPKM 33.7) and 25 other tissues.

Summary

This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of Phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced Antiviral responses. [provided by RefSeq, May 2022]

PLSCR1 Products(13)

mRNA Protein Name
NM_001363872.1 NP_001350801.1 phospholipid scramblase 1 isoform 2
NM_001363874.1 NP_001350803.1 phospholipid scramblase 1 isoform 3
NM_001406033.1 NP_001392962.1 phospholipid scramblase 1 isoform 4
NM_001406034.1 NP_001392963.1 phospholipid scramblase 1 isoform 1
NM_001406035.1 NP_001392964.1 phospholipid scramblase 1 isoform 1
NM_001406036.1 NP_001392965.1 phospholipid scramblase 1 isoform 5
NM_001406037.1 NP_001392966.1 phospholipid scramblase 1 isoform 6
NM_001406038.1 NP_001392967.1 phospholipid scramblase 1 isoform 3
NM_001406039.1 NP_001392968.1 phospholipid scramblase 1 isoform 3
NM_001406040.1 NP_001392969.1 phospholipid scramblase 1 isoform 3
NM_001406041.1 NP_001392970.1 phospholipid scramblase 1 isoform 3
NM_001406042.1 NP_001392971.1 phospholipid scramblase 1 isoform 7
NM_021105.3 NP_066928.1 phospholipid scramblase 1 isoform 1

PLSCR1 Protein Structure

Scramblase

Scramblase: Scramblase (86 - 306)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
Protein Preferred Names Protein Names

phospholipid scramblase 1

PL scramblase 1

Related Diseases

Diseases Alias
Scott Syndrome

SCTS

Bdplt7

Prothrombin Consumption Deficiency

Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X

Bleeding Disorder, Platelet-Type, 7

Prothrombin Conversion Defect, Familial

Prothrombin Consumption Inhibitor, Familial

Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X

Familial Prothrombin Consumption Inhibitor

Familial Prothrombin Conversion Defect

Platelet-Type Bleeding Disorder 7

Platelet Factor X Receptor Deficiency

Bleeding Disorder Platelet-Type 7

Prothrombin Consumption Inhibitor Familial

Prothrombin Conversion Defect Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10741 PLSCR1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLSCR1 RGD RGD:620521
Mus musculus PLSCR1 MGD MGI:893575