2. Gene
  3. POU6F1 - POU class 6 homeobox 1 Gene

POU6F1 - POU class 6 homeobox 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BRN5; MPOU; TCFB1

Gene ID: 5463 | Gene type: protein coding

About POU6F1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,186,936-51,218,062 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 17 paralogues. Ubiquitous expression in brain (RPKM 4.7), ovary (RPKM 3.6) and 23 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in actin Cytoskeleton and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

POU6F1 Products(3)

mRNA Protein Name
NM_001330422.2 NP_001317351.1 POU domain, class 6, transcription factor 1 isoform 2
NM_001351088.2 NP_001338017.1 POU domain, class 6, transcription factor 1 isoform 3
NM_001368008.1 NP_001354937.1 POU domain, class 6, transcription factor 1 isoform 3

POU6F1 Protein Structure

Pou

Pou: Pou domain - N-terminal to homeobox domain (140 - 213)

Homeobox

Homeobox: Homeobox domain (235 - 290)

  • 0
  • 100
  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

POU domain, class 6, transcription factor 1

brain-5

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10912 POU6F1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus POU6F1 VGNC VGNC:68970
Bos taurus POU6F1 VGNC VGNC:33180
Macaca mulatta POU6F1 VGNC VGNC:100092
Rattus norvegicus POU6F1 RGD RGD:620615
Canis familiaris POU6F1 VGNC VGNC:58326
Mus musculus POU6F1 MGD MGI:102935