2. Gene
  3. CROT - carnitine O-octanoyltransferase Gene

CROT - carnitine O-octanoyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as COT

Gene ID: 54677 | Gene type: protein coding

About CROT

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:87,345,664-87,399,794 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 12.0), urinary bladder (RPKM 8.5) and 22 other tissues.

Summary

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

CROT Products(3)

mRNA Protein Name
NM_001143935.2 NP_001137407.1 peroxisomal carnitine O-octanoyltransferase isoform 1
NM_001243745.3 NP_001230674.1 peroxisomal carnitine O-octanoyltransferase isoform 3
NM_021151.4 NP_066974.2 peroxisomal carnitine O-octanoyltransferase isoform 2

CROT Protein Structure

Carn_acyltransf

Carn_acyltransf: Choline/Carnitine o-acyltransferase (19 - 604)

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  • 612 a.a.
Protein Preferred Names Protein Names

peroxisomal carnitine O-octanoyltransferase

peroxisomal carnitine acyltransferase

Recombinant CROT Proteins

Cat. No. Product Name Accession Purity
HY-P74218 CROT Protein, Human (V474L, sf9, His) Q9UKG9-1 (M1-L612,V474L) ≥95%

Related Diseases

Diseases Alias
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03194 CROT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CROT VGNC VGNC:27723
Rattus norvegicus CROT RGD RGD:70908
Felis catus CROT VGNC VGNC:61188
Macaca mulatta CROT VGNC VGNC:71495
Mus musculus CROT MGD MGI:1921364
Canis familiaris CROT VGNC VGNC:39627
Others CROT NCBI