SPDL1 - spindle apparatus coiled-coil protein 1 Gene

Homo sapiens

Also known as CCDC99

Gene ID: 54908 | Gene type: protein coding

About SPDL1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:169,583,773-169,604,778 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in testis (RPKM 14.1), lymph node (RPKM 4.5) and 21 other tissues.

Summary

This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016]

SPDL1 Products(6)

mRNA	Protein	Name
NM_001329639.2	NP_001316568.1	protein Spindly isoform a
NM_001329640.2	NP_001316569.1	protein Spindly isoform a
NM_001329641.2	NP_001316570.1	protein Spindly isoform b
NM_001329642.2	NP_001316571.1	protein Spindly isoform c
NM_001329643.2	NP_001316572.1	protein Spindly isoform d
NM_017785.5	NP_060255.3	protein Spindly isoform b

Protein Preferred Names

Protein Names

protein Spindly

arsenite-related gene 1 protein

Related Diseases

Diseases

Alias

Postinflammatory Pulmonary Fibrosis

Post-Inflammatory Pulmonary Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13653	SPDL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SPDL1	VGNC	VGNC:77992
Felis catus	SPDL1	VGNC	VGNC:97641
Rattus norvegicus	SPDL1	RGD	RGD:1306908
Canis familiaris	SPDL1	VGNC	VGNC:46727
Mus musculus	SPDL1	MGD	MGI:1917635
Bos taurus	SPDL1	VGNC	VGNC:50114

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