SSH3 - slingshot protein phosphatase 3 Gene

Homo sapiens

Also known as SSH3L

Gene ID: 54961 | Gene type: protein coding

About SSH3

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,303,530-67,312,592 (from NCBI)

This gene has 11 transcripts (splice variants), 193 orthologues and 30 paralogues. Ubiquitous expression in urinary bladder (RPKM 17.7), prostate (RPKM 14.2) and 25 other tissues.

Summary

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

SSH3 Products(1)

mRNA	Protein	Name
NM_017857.4	NP_060327.3	protein phosphatase Slingshot homolog 3

SSH3 Protein Structure

DEK_C

DSPc

0
200
400
600
659 a.a.

Protein Preferred Names

Protein Names

protein phosphatase Slingshot homolog 3

SSH-3L

Related Diseases

Diseases

Alias

Epilepsy, Idiopathic Generalized 17

Febrile Seizures, Familial, 2	EIG17
Familial Febrile Seizures 2	FEB2
Epilepsy, Idiopathic Generalized, Susceptibility To, 17	Familial Febrile Convulsions 2
Convulsions, Familial Febrile, 2

Endosteal Hyperostosis, Autosomal Dominant

Osteosclerosis	Worth Syndrome
Osteosclerosis, Autosomal Dominant	Hyperostosis, Endosteal
Endosteal Hyperostosis, Worth Type	Worth Disease
Autosomal Dominant Endosteal Hyperostosis	Autosomal Dominant Osteosclerosis, Worth Type
Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus	Autosomal Dominant Osteosclerosis
Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus	Worth'S Syndrome
Worth Type Autosomal Dominant Osteosclerosis	Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus
Osteosclerosis, Autosomal Dominant, Worth Type	WENHY
Endosteal Hyperostosis Autosomal Dominant	Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus
Osteosclerosis Autosomal Dominant	Acquired Osteosclerosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13811	SSH3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SSH3	RGD	RGD:1308679
Felis catus	SSH3	VGNC	VGNC:65705
Canis familiaris	SSH3	VGNC	VGNC:46833
Macaca mulatta	SSH3	VGNC	VGNC:78019
Mus musculus	SSH3	MGD	MGI:2683546
Bos taurus	SSH3	VGNC	VGNC:35314

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