2. Gene
  3. PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP1A; PP-1A; PPP1A; PP1alpha

Gene ID: 5499 | Gene type: protein coding

About PPP1CA

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,398,183-67,401,858 (from NCBI)

This gene has 14 transcripts (splice variants), 177 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 67.2), colon (RPKM 56.9) and 25 other tissues.

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of Cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

PPP1CA Products(3)

mRNA Protein Name
NM_001008709.2 NP_001008709.1 serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3
NM_002708.4 NP_002699.1 serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1
NM_206873.2 NP_996756.1 serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 2

PPP1CA Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (59 - 250)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase PP1-alpha catalytic subunit

protein phosphatase 1, catalytic subunit, alpha isozyme

Related Diseases

Diseases Alias
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]
Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified
Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos
Coronavirus Infectious Disease
Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute

Rhino-Sinusitis

Rhinosinusitis

Common Colds

Acute Infective Rhinitis

Cold

Coryza

Head Cold

Infective Nasopharyngitis

Rhinopharyngitis

Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos

Epipharyngitis

Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation
Viral Pneumonia

Pneumonia, Viral

Acute Viral Pneumonia

Bronchopneumonia Due To Viruses Other Than Influenza Viruses

Interstitial Viral Pneumonia

Viral Bronchopneumonia

Viral Double Pneumonia

Viral Lobar Pneumonia

Viral Purulent Pneumonia

Virus Interstitial Pneumonia

Virus Lobar Pneumonia
Acute Diarrhea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10973 PPP1CA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPP1CA VGNC VGNC:106874
Felis catus PPP1CA VGNC VGNC:105823
Rattus norvegicus PPP1CA RGD RGD:3375
Mus musculus PPP1CA MGD MGI:103016
Macaca mulatta PPP1CA VGNC VGNC:76366