MOCOS - molybdenum cofactor sulfurase Gene

Homo sapiens

Also known as MCS; MOS; HMCS

Gene ID: 55034 | Gene type: protein coding

About MOCOS

Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38): 18:36,187,497-36,272,157 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in liver (RPKM 7.8), adrenal (RPKM 7.4) and 18 other tissues.

Summary

This gene encodes an Enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO Enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017]

MOCOS Products(1)

mRNA	Protein	Name
NM_017947.4	NP_060417.4	molybdenum cofactor sulfurase

MOCOS Protein Structure

Aminotran_5

MOSC_N

MOSC

0
200
400
600
800
888 a.a.

Protein Preferred Names

Protein Names

molybdenum cofactor sulfurase

Related Diseases

Diseases

Alias

Xanthinuria, Type Ii

Xanthinuria Type Ii	XAN2
Xdh And Aox Dual Deficiency	Xanthine Dehydrogenase And Aldehyde Oxidase, Combined Deficiency Of
Xanthinuria Type 2	Type 2 Xanthinuria
Type Ii Xanthinuria	Xanthine Dehydrogenase And Aldehyde Oxidase Combined Deficiency Of
Xanthine Dehydrogenase And Xanthine Aldehyde Oxidase Dual Deficiency	Xanthinuria 2
Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase	Xanthic Urolithiasis

Xanthinuria

Xanthine Dehydrogenase Deficiency	Xanthine Oxidase Deficiency
Hereditary Xanthinuria	Xanthic Urolithiasis
Xanthine Stone Disease	Xanthinuria, Type I
Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase	Xdh Deficiency
Classic Xanthinuria	Xanthinuria, Type Ii
Classical Xanthinuria	Xanthine Calculus

Purine-Pyrimidine Metabolic Disorder

Inborn Errors Of Purine-Pyrimidine Metabolism

Disorder Of Purine Or Pyrimidine Metabolism

Prolidase Deficiency

Hyperimidodipeptiduria	Imidodipeptidase Deficiency
Peptidase Deficiency	PD
Deficiency Of Prolidase	Imidodipeptiduria
Proline Dipeptidase Deficiency

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08579	MOCOS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MOCOS	RGD	RGD:1308496
Macaca mulatta	MOCOS	VGNC	VGNC:74792
Canis familiaris	MOCOS	VGNC	VGNC:43305
Felis catus	MOCOS	VGNC	VGNC:63549
Mus musculus	MOCOS	MGD	MGI:1915841
Bos taurus	MOCOS	VGNC	VGNC:31547

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