PPP1R2 - protein phosphatase 1 regulatory inhibitor subunit 2 Gene

Homo sapiens

Also known as IPP2; IPP-2; PPP1R2A

Gene ID: 5504 | Gene type: protein coding

About PPP1R2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,514,428-195,543,325 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 22.2) and 25 other tissues.

Summary

Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

PPP1R2 Products(4)

mRNA	Protein	Name
NM_001291504.2	NP_001278433.1	protein phosphatase inhibitor 2 isoform 1
NM_001291505.2	NP_001278434.1	protein phosphatase inhibitor 2 isoform 3
NM_001316325.2	NP_001303254.1	protein phosphatase inhibitor 2 isoform 4
NM_006241.8	NP_006232.1	protein phosphatase inhibitor 2 isoform 2

PPP1R2 Protein Structure

IPP-2

0
100
205 a.a.

Protein Preferred Names

Protein Names

protein phosphatase inhibitor 2

phosphoprotein phosphatase

Related Diseases

Diseases

Alias

Cataract 11, Multiple Types

Cataract, Posterior Polar, 4	Ctpp4
Cpp4	Cataract 11 Multiple Types
CTRCT11	Cataract 11, Syndromic, Autosomal Recessive
Cataract 11 With Microphthalmia And Neurodevelopmental Abnormalities	Posterior Polar Cataract 4
Posterior Polar Cataract, 4	Cataract Posterior Polar 4
Syndromic Cataract 11	Cataract, Type 11, Multiple Types

Pulmonary Talcosis

Pneumoconiosis Due To Talc	Talc Pneumoconiosis
Talcosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10995	PPP1R2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP1R2	RGD	RGD:621099
Mus musculus	PPP1R2	MGD	MGI:1914099

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