PDPR - pyruvate dehydrogenase phosphatase regulatory subunit Gene

Homo sapiens

Also known as PDP3

Gene ID: 55066 | Gene type: protein coding

About PDPR

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,113,626-70,163,427 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 9.0), brain (RPKM 8.9) and 25 other tissues.

Summary

Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase Phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

PDPR Products(4)

mRNA	Protein	Name
NM_001322117.1	NP_001309046.1	pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 1 precursor
NM_001322118.1	NP_001309047.1	pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 2
NM_001322119.1	NP_001309048.1	pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 3
NM_017990.5	NP_060460.4	pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform 1 precursor

PDPR Protein Structure

DAO

GCV_T

GCV_T_C

0
200
400
600
800
879 a.a.

Protein Preferred Names

Protein Names

pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

Related Diseases

Diseases

Alias

Anismus

Ghosal Hematodiaphyseal Dysplasia

Ghosal Syndrome	Ghosal Hematodiaphyseal Syndrome
GHDD	Diaphyseal Dysplasia-Anemia Syndrome
Ghosal Hematodiaphyseal Dysplasia Syndrome	Diaphyseal Dysplasia Associated With Anemia
Ghosal Hemato-Diaphyseal Dysplasia	Ghosal-Type Hemato-Diaphyseal Dysplasia

Spinocerebellar Ataxia 23

Spinocerebellar Ataxia Type 23	SCA23
Ataxia, Spinocerebellar, Type 23

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10289	PDPR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PDPR	RGD	RGD:1308307
Canis familiaris	PDPR	VGNC	VGNC:44390
Bos taurus	PDPR	VGNC	VGNC:32715
Mus musculus	PDPR	MGD	MGI:2442188
Macaca mulatta	PDPR	VGNC	VGNC:75897