2. Gene
  3. NEIL3 - nei like DNA glycosylase 3 Gene

NEIL3 - nei like DNA glycosylase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3

Gene ID: 55247 | Gene type: protein coding

About NEIL3

Cytogenetic location: 4q34.3 Genomic coordinates (GRCh38): 4:177,309,874-177,371,268 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 2.5), lymph node (RPKM 1.9) and 13 other tissues.

Summary

NEIL3 belongs to a class of DNA glycosylases homologous to the Bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by Reactive Oxygen Species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]

NEIL3 Products(1)

mRNA Protein Name
NM_018248.3 NP_060718.3 endonuclease 8-like 3

NEIL3 Protein Structure

H2TH

H2TH: Formamidopyrimidine-DNA glycosylase H2TH domain (165 - 227)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (317 - 345)

zf-GRF

zf-GRF: GRF zinc finger (506 - 548)

zf-GRF

zf-GRF: GRF zinc finger (552 - 595)

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  • 605 a.a.
Protein Preferred Names Protein Names

endonuclease 8-like 3

DNA glycosylase FPG2

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09189 NEIL3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NEIL3 VGNC VGNC:31990
Mus musculus NEIL3 MGD MGI:2384588
Macaca mulatta NEIL3 VGNC VGNC:75248
Rattus norvegicus NEIL3 RGD RGD:1310562
Canis familiaris NEIL3 VGNC VGNC:43728
Felis catus NEIL3 VGNC VGNC:63768