ETNK1 - ethanolamine kinase 1 Gene

Homo sapiens

Also known as EKI; EKI1; EKI 1; Nbla10396

Gene ID: 55500 | Gene type: protein coding

About ETNK1

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:22,625,171-22,690,665 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues, 3 paralogues and is associated with 61 phenotypes. Ubiquitous expression in stomach (RPKM 14.8), colon (RPKM 12.5) and 25 other tissues.

Summary

This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic Enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

ETNK1 Products(2)

mRNA	Protein	Name
NM_001039481.2	NP_001034570.2	ethanolamine kinase 1 isoform B
NM_018638.5	NP_061108.3	ethanolamine kinase 1 isoform A

ETNK1 Protein Structure

Choline_kinase

0
100
200
300
400
452 a.a.

Protein Preferred Names

Protein Names

ethanolamine kinase 1

putative protein product of Nbla10396

Related Diseases

Diseases

Alias

Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia	Atypical Chronic Myeloid Leukaemia
Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative	Acml
Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative
Atypical Cml	Subacute Myeloid Leukemia
Subacute Myelogenous Leukaemia	Subacute Myeloid Leukaemia
Subacute Myelosis	Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission
Subacute Monocytic Leukaemia Without Mention Of Remission	Subacute Monocytic Leukaemia

Myelodysplastic/Myeloproliferative Neoplasm

Myelodysplastic-Myeloproliferative Diseases	Myelodysplastic/Myeloproliferative Disease
Myelodysplastic Myeloproliferative Cancer	Myelodysplastic Myeloproliferative Disease
Myeloproliferative/Myelodysplastic Syndromes

Chronic Neutrophilic Leukemia

Cnl	Leukemia Neutrophilic Chronic

Bladder Neck Obstruction

Obstruction Of Bladder Neck Or Vesicourethral Orifice	Urinary Bladder Neck Obstruction
Bladder Outlet Obstruction	Vesicourethral Orifice Obstruction
Bno - [Bladder Neck Obstruction]	Bladder Obstruction Nos
Acquired Bladder Neck Obstruction	Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice
Bladder Neck Strangulation	Bladder Neck Stricture
Bladder Outflow Obstruction	Contracture Of Bladder Neck Or Sphincter
Contracture Of Bladder Neck	Obstructed Vesicourethral Orifice
Strangulation Of Vesicourethral Orifice	Stricture Of Vesicourethral Orifice
Urinary Prostatic Valve Obstruction	Vesical Obstruction

Chronic Leukemia

Adult Chronic Leukemia	Cll
Cml

Aggressive Systemic Mastocytosis

Asm	Lymphadenopathic Mastocytosis With Eosinophilia

Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic	Cmml
Leukemia Myelomonocytic Chronic	Cmml - [Chronic Myelomonocytic Leukaemia]
Chronic Myelomonocytic Leukaemia Without Mention Of Remission	Chronic Monocytic Leukaemia
Chronic Monocytoid Leukaemia

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic	JMML
Leukemia, Juvenile Myelomonocytic, Somatic	Juvenile Chronic Myelomonocytic Leukemia
Juvenile Chronic Myelogenous Leukemia	Leukemia, Myelomonocytic, Juvenile
Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04559	ETNK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ETNK1	VGNC	VGNC:61978
Macaca mulatta	ETNK1	VGNC	VGNC:72329
Canis familiaris	ETNK1	VGNC	VGNC:40492
Rattus norvegicus	ETNK1	RGD	RGD:1308204
Mus musculus	ETNK1	MGD	MGI:1922570
Bos taurus	ETNK1	VGNC	VGNC:28624

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