2. Gene
  3. PLXNA3 - plexin A3 Gene

PLXNA3 - plexin A3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as 6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE

Gene ID: 55558 | Gene type: protein coding

About PLXNA3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,458,281-154,477,779 (from NCBI)

This gene has 9 transcripts (splice variants), 193 orthologues and 8 paralogues. Ubiquitous expression in skin (RPKM 7.2), ovary (RPKM 7.2) and 25 other tissues.

Summary

This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as Apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

PLXNA3 Products(1)

mRNA Protein Name
NM_017514.5 NP_059984.3 plexin-A3 precursor

PLXNA3 Protein Structure

Sema

Sema: Sema domain (34 - 468)

PSI

PSI: Plexin repeat (490 - 539)

PSI

PSI: Plexin repeat (637 - 684)

PSI

PSI: Plexin repeat (788 - 837)

TIG

TIG: IPT/TIG domain (840 - 926)

TIG

TIG: IPT/TIG domain (935 - 1019)

TIG

TIG: IPT/TIG domain (1023 - 1120)

TIG

TIG: IPT/TIG domain (1139 - 1201)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1293 - 1841)

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  • 1871 a.a.
Protein Preferred Names Protein Names

plexin-A3

Sex chromosome X transmembrane protein of HGF receptor family 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10750 PLXNA3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PLXNA3 VGNC VGNC:44720
Mus musculus PLXNA3 MGD MGI:107683
Macaca mulatta PLXNA3 VGNC VGNC:76185
Rattus norvegicus PLXNA3 RGD RGD:1584973
Felis catus PLXNA3 VGNC VGNC:82453